PXD055837

PXD055837 is an original dataset announced via ProteomeXchange.

Title	Proteomics of isolated human cerebral vessels and whole tissue
Description	Cerebral vasculature is critical in maintaining brain health, as its dysfunction is linked to various neurological illnesses including dementia and stroke. Proteomic studies are integral in understanding the biological mechanism underlying this dysfunction, identifying potential therapeutic targets and novel biomarkers of disease. However, translation of research findings into clinical practice relies on the validity and reproducibility of its methods. Thus, we have developed a novel protocol for the extraction of human cerebral vasculature which is highly compatible with downstream proteomic analyses. This protocol negates the need for bovine serum albumin, a ubiquitous reagent in vessel isolation protocols, yet an undesirable contaminant in proteomics.
HostingRepository	PRIDE
AnnounceDate	2025-09-11
AnnouncementXML	Submission_2025-09-11_10:28:18.278.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Blanca Díaz Castro
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	iodoacetamide derivatized residue
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2024-09-13 01:40:19	ID requested
⏵ 1	2025-09-11 10:28:18	announced

Dataset with its publication pending

submitter keyword: brain, DIA, vasculature,human, isolation, healthy

Blanca Diaz-Castro
contact affiliation	UK Dementia Research Institute, University of Edinburgh
contact email	B.Diaz-Castro@ed.ac.uk
lab head
Blanca Díaz Castro
contact affiliation	University of Edinburgh and UK Dementia Research Institute
contact email	b.diaz-castro@ed.ac.uk
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/09/PXD055837

PRIDE project URI

• PRIDE
  1. PXD055837
     1. Label: PRIDE project
     2. Name: Proteomics of isolated human cerebral vessels and whole tissue