PXD055743

PXD055743 is an original dataset announced via ProteomeXchange.

Title	Reliability of Serum-Derived Connectome Indicators in Identifying Cirrhosis
Description	Patients with cirrhosis are at a relatively high risk of developing complications, such as hepatic decompensation and hepatocellular carcinoma. Identifying cirrhosis in patients is essential in clinical practice because of the need to control disease progression and select different treatment strategies. Moreover, early diagnosis of cirrhosis is conducive to preventing the development of severe complications. Liver biopsy is considered the gold standard for determining cirrhosis, but most patients are unwilling to accept the invasive procedure because of the inconvenience and potential risk. We have developed a Connectome strategy that combines metabolites with peptide spectral matching(PSMs) in proteomics to integrate metabolomics and proteomics, identifying specific metabolites bound to blood proteins in cirrhosis using open search proteomics methods.
HostingRepository	PRIDE
AnnounceDate	2025-07-23
AnnouncementXML	Submission_2025-07-23_09:46:59.421.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Jisheng Guo
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	(R)-5-oxo-1; dehydrated residue; palmitoylated residue; phosphorylated residue; myristoylated residue; acetylated residue; deaminated residue; deamidated residue; iodoacetamide derivatized residue; carbamoylated residue; amidated residue; monohydroxylated residue; formylated residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2024-09-09 06:57:32	ID requested
⏵ 1	2025-07-23 09:46:59	announced

Dataset with its publication pending

submitter keyword: Connectome strategy

Proteomics

Open search

Post-translational modifications

Peptide spectral matches

Jisheng Guo
contact affiliation	Yantai Campus of Binzhou Medical University,China.
contact email	guojisheng@bzmc.edu.cn
lab head
Jisheng Guo
contact affiliation	binzhou medical university
contact email	guojisheng@bzmc.edu.cn
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/07/PXD055743

PRIDE project URI

• PRIDE
  1. PXD055743
     1. Label: PRIDE project
     2. Name: Reliability of Serum-Derived Connectome Indicators in Identifying Cirrhosis