PXD055025
PXD055025 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Proteomic Analysis Reveals Differential Protein Expression in Early-Onset Preeclampsia Patients |
| Description | Preeclampsia, a significant cause of maternal and perinatal morbidity and mortality, remains poorly understood in terms of its pathogenesis. This study aims to uncover novel and effective biomarkers for preeclampsia by conducting a comparative analysis of differential proteins in placentas from early-onset preeclampsia (EOPE) and normal pregnancies. Utilizing tandem mass tag (TMT)-based quantitative proteomics, we identified differentially expressed proteins in placental tissues from 15 EOPE patients and 15 normal pregnant women. These proteins were subsequently validated using parallel reaction monitoring (PRM). Our analysis revealed a total of 59 differentially expressed proteins, with 25 up-regulated and 34 down-regulated in EOPE placental tissues compared to those from normal pregnancies. Validation through PRM confirmed the differential expression of 6 proteins. Our findings suggest these 6 proteins could play crucial roles in the pathogenesis of EOPE, highlighting the potential involvement of the Estrogen signaling pathway and Dilated cardiomyopathy (DCM) pathway in the development of preeclampsia. |
| HostingRepository | iProX |
| AnnounceDate | 2024-08-20 |
| AnnouncementXML | Submission_2024-08-20_20:04:26.423.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Jing Li |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Q Exactive |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2024-08-20 19:20:29 | ID requested | |
| ⏵ 1 | 2024-08-20 20:04:26 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: preeclampsia, early-onset preeclampsia (EOPE), biomarkers, proteomics |
Contact List
| Jing Li | |
|---|---|
| contact affiliation | The Affiliated Hospital of Qingdao University |
| contact email | lijing@qdu.edu.cn |
| lab head | |
| Jing Li | |
| contact affiliation | The Affiliated Hospital of Qingdao University |
| contact email | lijing@qdu.edu.cn |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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