PXD054551 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Trioxane-based MS-cleavable Cross-linking Mass Spectrometry for Profiling Multimeric Interactions of Cellular Networks |
Description | Here, we present a novel trioxane-based MS-cleavable homotrifunctional cross-linker TSTO, which can target three proximal lysine residues simultaneously. Owing to its unique structure and MS-cleavability, TSTO enables fast and unambiguous identification of cross-linked peptides using LC-MSn analysis. Importantly, we have demonstrated that the TSTO-based XL-MS platform is effective for mapping PPIs of protein complexes and cellular networks. |
HostingRepository | PRIDE |
AnnounceDate | 2025-05-30 |
AnnouncementXML | Submission_2025-05-30_11:21:02.011.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Clinton Yu |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | monohydroxylated residue; iodoacetamide derivatized residue |
Instrument | Orbitrap Fusion Lumos |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2024-08-03 02:12:21 | ID requested | |
⏵ 1 | 2025-05-30 11:21:02 | announced | |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: TSTO,XL-MS, cross-linking mass spectrometry |
Contact List
Lan Huang |
contact affiliation | Department of Physiology & Biophysics, University of California, Irvine, Irvine, CA 92697, USA |
contact email | lanhuang@uci.edu |
lab head | |
Clinton Yu |
contact affiliation | University of California, Irvine |
contact email | clinton.yu@uci.edu |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD054551
- Label: PRIDE project
- Name: Trioxane-based MS-cleavable Cross-linking Mass Spectrometry for Profiling Multimeric Interactions of Cellular Networks