PXD053948

PXD053948 is an original dataset announced via ProteomeXchange.

Title	A WYL transcription factor regulates Lactiplantibacillus plantarum intestinal colonization via perceiving c-di-GMP
Description	The WYL transcription factor (LP_RS00300) is a c-di-GMP effector in L. plantarum WCFS1. LP_RS00300 binds to a special motif within the coding sequence, impeding the transcriptional elongation of LP_RS05345 and LP_RS05225, which encode mucus binding proteins (MucBPs). The perception of c-di-GMP by the WYL domain reversed the inhibitory effect of LP_RS00300 on the expression of MucBPs, resulting in increased adherence to intestinal epithelial cells by L. plantarum. Overall, our study provides evidence that a WYL transcription factor participates in probiotic colonization by sensing c-di-GMP.
HostingRepository	PRIDE
AnnounceDate	2025-02-14
AnnouncementXML	Submission_2025-02-13_17:03:27.920.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	quan Guo
SpeciesList	scientific name: Lactobacillus plantarum WCFS1; NCBI TaxID: 220668; scientific name: Bacteria; NCBI TaxID: NCBITaxon:2;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Exploris 480

Revision	Datetime	Status	ChangeLog Entry
0	2024-07-15 04:49:57	ID requested
⏵ 1	2025-02-13 17:03:28	announced

Dataset with its publication pending

submitter keyword: c-di-GMP receptor, WYL transcription factor,Lactiplantibacillus plantarum

Quan Guo
contact affiliation	School of Food Science and Engineering, Key Laboratory of Food Nutrition and Functional Food of Hainan Province, Hainan University, Haikou 570228, China Collaborative Innovation Center of One Health, Hainan University
contact email	guoq@hainanu.edu.cn
lab head
quan Guo
contact affiliation	Hainan University
contact email	guoq@hainanu.edu.cn
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/02/PXD053948

PRIDE project URI

• PRIDE
  1. PXD053948
     1. Label: PRIDE project
     2. Name: A WYL transcription factor regulates Lactiplantibacillus plantarum intestinal colonization via perceiving c-di-GMP