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PXD053633

PXD053633 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleIn vivo fitness of sul gene-dependent sulfonamide-resistant Escherichia coli in the mammalian gut
DescriptionSulfonamides are traditional synthetic antimicrobial agents used in clinical and veterinary medical settings. Their long-term excessive overuse has resulted in widespread microbial resistance, limiting their application for medical interventions. Resistance to sulfonamides is primarily conferred by the alternative genes sul1, sul2, and sul3 encoding dihydropteroate synthase in bacteria. Studying the potential fitness cost of these sul genes is crucial for understanding the evolution and transmission of sulfonamide-resistant bacteria. In vitro studies have been conducted on the fitness cost of sul genes in bacteria. In this study, we provide critical insights into bacterial adaptation and transmission using an in vivo approach.
HostingRepositoryiProX
AnnounceDate2024-07-04
AnnouncementXMLSubmission_2024-07-03_23:49:42.941.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterJiehong Fang
SpeciesList scientific name: Escherichia coli str. K-12 substr. MG1655; NCBI TaxID: 511145;
ModificationListNo PTMs are included in the dataset
InstrumentQ Exactive
Dataset History
RevisionDatetimeStatusChangeLog Entry
02024-07-03 23:48:36ID requested
12024-07-03 23:49:43announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: Sulfonamide resistance gene, Fitness cost, In vivo, Quantitative proteomic method, E. coli
Contact List
Jiehong Fang
contact affiliationChina Jiliang University
contact emailfangjh@cjlu.edu.cn
lab head
Jiehong Fang
contact affiliationChina Jiliang University
contact emailfangjh@cjlu.edu.cn
dataset submitter
Full Dataset Link List
iProX dataset URI