PXD053359 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Deep Plasma Proteome Profiling by Modulating Single Nanoparticle Protein Corona with Small Molecules |
Description | The protein corona, a dynamic biomolecular layer that forms on nanoparticle (NP) surfaces upon exposure to biological fluids is emerging as a valuable diagnostic tool for improving plasma proteome coverage analyzed by liquid chromatography-mass spectrometry (LC-MS/MS). Here, we show that spiking phosphatidylcholine into plasma can induce diverse protein corona patterns on otherwise identical NPs, significantly enhancing the depth of plasma proteome profiling. This significant achievement is made utilizing only a single NP type and one small molecule to analyze a single plasma sample, setting a new standard in proteomic depth of the plasma sample. Given the critical role of plasma proteomics in biomarker discovery and disease monitoring, we anticipate widespread adoption of this methodology for identification and clinical translation of proteomic biomarkers into FDA approved diagnostics. |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-15 |
AnnouncementXML | Submission_2024-10-15_05:04:55.311.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Liangliang Sun |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | No PTMs are included in the dataset |
Instrument | Q Exactive HF |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2024-06-24 08:40:31 | ID requested | |
⏵ 1 | 2024-10-15 05:04:56 | announced | |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: Protein Corona, Top Down Proteomics, Human plasma, Bottom Up Proteomics, Nanoparticles |
Contact List
Liangliang Sun |
contact affiliation | Michigan State University |
contact email | lsun@chemistry.msu.edu |
lab head | |
Liangliang Sun |
contact affiliation | Michigan State University |
contact email | lsun@chemistry.msu.edu |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/10/PXD053359 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD053359
- Label: PRIDE project
- Name: Deep Plasma Proteome Profiling by Modulating Single Nanoparticle Protein Corona with Small Molecules