PXD052976 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Haplotype variability in mitochondrial rRNA predisposes to metabolic syndrome |
Description | Metabolic syndrome is a growing concern in developed societies and due to its polygenic nature, the genetic component is only slowly being elucidated. Common mitochondrial DNA sequence variants have been associated with symptoms of metabolic syndrome and may therefore be relevant players in the genetics of metabolic syndrome. We investigate the effect of mitochondrial sequence variation on the metabolic phenotype in conplastic rat strains with identical nuclear but unique mitochondrial genomes, challenged by high-fat diet. We find that the variation in mitochondrial rRNA sequence represents risk factor in the insulin resistance development, which is caused by diacylglycerols accumulation induced by tissue-specific reduction of the oxidative capacity. These metabolic perturbations stem from the 12S rRNA sequence variation affecting mitochondrial ribosome assembly and translation. Our work demonstrates that physiological variation in mitochondrial rRNA might represent a relevant underlying factor in the progression of metabolic syndrome. |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-22 |
AnnouncementXML | Submission_2024-10-22_06:54:52.270.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Marek Vrbacky |
SpeciesList | scientific name: Rattus norvegicus (Rat); NCBI TaxID: 10116; |
ModificationList | iodoacetamide derivatized residue |
Instrument | Orbitrap Exploris 480 |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2024-06-10 14:58:52 | ID requested | |
1 | 2024-08-13 03:26:14 | announced | |
⏵ 2 | 2024-10-22 06:54:52 | announced | 2024-10-22: Updated project metadata. |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: metabolic syndrome, diacylglycerols, mitochondrial haplotype, insulin signaling |
Contact List
Tomas Mracek |
contact affiliation | Laboratory of Bioenergetics Institute of Physiology of the Czech Academy of Sciences Prague, Czech Republic |
contact email | tomas.mracek@fgu.cas.cz |
lab head | |
Marek Vrbacky |
contact affiliation | Czech Academy of Sciences |
contact email | proteom.krc@gmail.com |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD052976
- Label: PRIDE project
- Name: Haplotype variability in mitochondrial rRNA predisposes to metabolic syndrome