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PXD052976

PXD052976 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleHaplotype variability in mitochondrial rRNA predisposes to metabolic syndrome
DescriptionMetabolic syndrome is a growing concern in developed societies and due to its polygenic nature, the genetic component is only slowly being elucidated. Common mitochondrial DNA sequence variants have been associated with symptoms of metabolic syndrome and may therefore be relevant players in the genetics of metabolic syndrome. We investigate the effect of mitochondrial sequence variation on the metabolic phenotype in conplastic rat strains with identical nuclear but unique mitochondrial genomes, challenged by high-fat diet. We find that the variation in mitochondrial rRNA sequence represents risk factor in the insulin resistance development, which is caused by diacylglycerols accumulation induced by tissue-specific reduction of the oxidative capacity. These metabolic perturbations stem from the 12S rRNA sequence variation affecting mitochondrial ribosome assembly and translation. Our work demonstrates that physiological variation in mitochondrial rRNA might represent a relevant underlying factor in the progression of metabolic syndrome.
HostingRepositoryPRIDE
AnnounceDate2024-10-22
AnnouncementXMLSubmission_2024-10-22_06:54:52.270.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterMarek Vrbacky
SpeciesList scientific name: Rattus norvegicus (Rat); NCBI TaxID: 10116;
ModificationListiodoacetamide derivatized residue
InstrumentOrbitrap Exploris 480
Dataset History
RevisionDatetimeStatusChangeLog Entry
02024-06-10 14:58:52ID requested
12024-08-13 03:26:14announced
22024-10-22 06:54:52announced2024-10-22: Updated project metadata.
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: metabolic syndrome, diacylglycerols, mitochondrial haplotype, insulin signaling
Contact List
Tomas Mracek
contact affiliationLaboratory of Bioenergetics Institute of Physiology of the Czech Academy of Sciences Prague, Czech Republic
contact emailtomas.mracek@fgu.cas.cz
lab head
Marek Vrbacky
contact affiliationCzech Academy of Sciences
contact emailproteom.krc@gmail.com
dataset submitter
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Dataset FTP location
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