PXD052963

PXD052963 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Stress-induced condensation of TDP-43 in the nucleus
Description	TDP-43 is an RNA-binding protein ubiquitously dysregulated in neurodegeneration. We found that under stress conditions, TDP-43 undergoes reversible condensation in the nucleus of cultured cells including human neurons. These condensates (“TCs”) are non-liquid assemblies with low dynamic properties. Their proteomic analysis and subsequent comparison with the normal (soluble) TDP-43 interactome revealed that upon condensate partitioning, TDP-43 dissociates from its normal protein binding partners. We propose that the main function of TCs is rapid but reversible inactivation of TDP-43 during stress. This can help fine-tune the splicing patterns under stress to enable efficient stress response and survival.
HostingRepository	jPOST
AnnounceDate	2024-06-10
AnnouncementXML	Submission_2024-06-10_06:31:43.838.xml
DigitalObjectIdentifier
ReviewLevel	Non peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	WAN-PING HUANG
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	S-carboxamidomethyl-L-cysteine; L-methionine sulfoxide; alpha-amino acetylated residue; Met-loss+Acetyl
Instrument	instrument

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2024-06-10 06:31:40	ID requested
⏵ 1	2024-06-10 06:31:44	announced

Publication List

Dataset with its publication pending

Dataset with its publication pending

Keyword List

submitter keyword: TDP-43, nuclear condensate, stress response

submitter keyword: TDP-43, nuclear condensate, stress response

Contact List

Tatyana Shelkovnikova
lab head
WAN-PING HUANG
contact affiliation	SITraN
dataset submitter

Full Dataset Link List

jPOST dataset URI
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jPOST dataset URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.jpostdb.org/JPST003167/