PXD052695
PXD052695 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | EIF4G2 Promotes HCC Progression |
| Description | Aberrant translation from mRNAs to proteins plays a crucial role in the pathogenesis of various cancers. Here, we revealed that the key proteins involved in translation were up-regulated in two hepatocellular carcinoma (HCC) cohorts. Specifically, we identified the translation initiation factor EIF4G2 as a marker of poor prognosis, linked to unfavorable overall survival (OS) outcomes. Our in vitro and in vivo studies confirmed that EIF4G2 promotes the development and metastasis of HCC. As an essential translation initiation factor, EIF4G2 knockdown disrupts polyribosome stability and inhibits nascent protein synthesis in the Huh-7 and MHCC97H cell lines. By com-paring the proteome and transcriptome of Huh-7 cells, we further identified PLEKHA1 as an essential target of EIF4G2 with IRES-dependent translation. PLEKHA1 was able to rescue the inhibitory effects of EIF4G2 knockdown on cell migration and invasion in both Huh-7 and MHCC97H cells. This research provides novel insights into the critical role of EIF4G2-dependent translation in cancer, where PLEKHA1 promotes HCC progression. |
| HostingRepository | iProX |
| AnnounceDate | 2024-05-30 |
| AnnouncementXML | Submission_2024-05-29_20:17:24.929.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Manman Li |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | LTQ |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2024-05-29 20:15:35 | ID requested | |
| ⏵ 1 | 2024-05-29 20:17:25 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: Hepatocellular carcinoma, Proteome, Translation-related proteins, EIF4G2, PLEKHA1, IRES-dependent translation, Tumor metastasis |
Contact List
| Ying Jiang | |
|---|---|
| contact affiliation | National Center for Protein Sciences (Beijing) |
| contact email | jiangying@ncpsb.org.cn |
| lab head | |
| Manman Li | |
| contact affiliation | National Center for Protein Sciences (Beijing) |
| contact email | limanman@ncpsb.org.cn |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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