PXD052426
PXD052426 is an original dataset announced via ProteomeXchange.
Dataset Summary
Title | Chemical proteomic profiling of protein dopaminylation in colorectal cancer cells |
Description | Histone dopaminylation is a newly identified epigenetic mark that plays a role in the regulation of gene transcription, where an isopeptide bond is formed between the fifth amino acid residue of H3 (i.e., glutamine) and dopamine. In our previous studies, we discovered that the dynamics of this post-translational modification (including installation, removal, and replacement) were regulated by a single enzyme, transglutaminase 2 (TGM2), through reversible transamination. Recently, we developed a chemical probe to specifically label and enrich histone dopaminylation via bioorthogonal chemistry. |
HostingRepository | iProX |
AnnounceDate | 2024-05-21 |
AnnouncementXML | Submission_2024-05-20_20:05:24.661.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Nan |
SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
ModificationList | iodoacetamide derivatized residue |
Instrument | timsTOF Pro |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
---|---|---|---|
0 | 2024-05-20 20:04:59 | ID requested | |
⏵ 1 | 2024-05-20 20:05:25 | announced |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: Probe, proteomic, dopaminylation |
Contact List
Qingfei Zheng | |
---|---|
contact affiliation | The Ohio State University |
contact email | nanzhangwe@outlook.com |
lab head | |
Nan | |
contact affiliation | The Ohio State University |
contact email | bukesiyi1100@126.com |
dataset submitter |
Full Dataset Link List
iProX dataset URI |