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PXD052426

PXD052426 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleChemical proteomic profiling of protein dopaminylation in colorectal cancer cells
DescriptionHistone dopaminylation is a newly identified epigenetic mark that plays a role in the regulation of gene transcription, where an isopeptide bond is formed between the fifth amino acid residue of H3 (i.e., glutamine) and dopamine. In our previous studies, we discovered that the dynamics of this post-translational modification (including installation, removal, and replacement) were regulated by a single enzyme, transglutaminase 2 (TGM2), through reversible transamination. Recently, we developed a chemical probe to specifically label and enrich histone dopaminylation via bioorthogonal chemistry.
HostingRepositoryiProX
AnnounceDate2024-05-21
AnnouncementXMLSubmission_2024-05-20_20:05:24.661.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterNan
SpeciesList scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationListiodoacetamide derivatized residue
InstrumenttimsTOF Pro
Dataset History
RevisionDatetimeStatusChangeLog Entry
02024-05-20 20:04:59ID requested
12024-05-20 20:05:25announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: Probe, proteomic, dopaminylation
Contact List
Qingfei Zheng
contact affiliationThe Ohio State University
contact emailnanzhangwe@outlook.com
lab head
Nan
contact affiliationThe Ohio State University
contact emailbukesiyi1100@126.com
dataset submitter
Full Dataset Link List
iProX dataset URI