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PXD052378

PXD052378 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleRegulation of Drosophila brain development and organ growth by the Minibrain/Rala signaling network
DescriptionUsing affinity purification-mass spectrometry (AP-MS), we identified the novel Mnb binding partners Ral interacting protein (Rlip) and RALBP1 associated Eps domain containing (Reps). Rlip and Reps physically and genetically interact with Mnb, and the three proteins may form a ternary complex. Mnb phosphorylates Reps, and human DYRK1A binds to the Reps orthologs REPS1 and REPS2. Furthermore, Mnb engages the small GTPase Ras-like protein A (Rala) to regulate brain and wing development. This work uncovers a previously unrecognized early role of Mnb in the neuroepithelium and defines the functions of the Mnb/Reps/Rlip/Rala signaling network in brain development.
HostingRepositoryPRIDE
AnnounceDate2024-10-22
AnnouncementXMLSubmission_2024-10-22_06:57:49.760.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterAlexey Veraksa
SpeciesList scientific name: Drosophila melanogaster (Fruit fly); NCBI TaxID: 7227;
ModificationListiodoacetic acid derivatized residue
InstrumentLTQ Orbitrap
Dataset History
RevisionDatetimeStatusChangeLog Entry
02024-05-19 10:17:21ID requested
12024-09-09 09:07:54announced
22024-10-22 06:57:50announced2024-10-22: Updated project metadata.
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: embryo,Drosophila, Minibrain
Contact List
Alexey Veraksa
contact affiliationUniversity of Massachusetts Boston
contact emailalexey.veraksa@umb.edu
lab head
Alexey Veraksa
contact affiliationUniversity of Massachusetts Boston
contact emailalexey.veraksa@umb.edu
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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