PXD052378 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Regulation of Drosophila brain development and organ growth by the Minibrain/Rala signaling network |
Description | Using affinity purification-mass spectrometry (AP-MS), we identified the novel Mnb binding partners Ral interacting protein (Rlip) and RALBP1 associated Eps domain containing (Reps). Rlip and Reps physically and genetically interact with Mnb, and the three proteins may form a ternary complex. Mnb phosphorylates Reps, and human DYRK1A binds to the Reps orthologs REPS1 and REPS2. Furthermore, Mnb engages the small GTPase Ras-like protein A (Rala) to regulate brain and wing development. This work uncovers a previously unrecognized early role of Mnb in the neuroepithelium and defines the functions of the Mnb/Reps/Rlip/Rala signaling network in brain development. |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-22 |
AnnouncementXML | Submission_2024-10-22_06:57:49.760.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Alexey Veraksa |
SpeciesList | scientific name: Drosophila melanogaster (Fruit fly); NCBI TaxID: 7227; |
ModificationList | iodoacetic acid derivatized residue |
Instrument | LTQ Orbitrap |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2024-05-19 10:17:21 | ID requested | |
1 | 2024-09-09 09:07:54 | announced | |
⏵ 2 | 2024-10-22 06:57:50 | announced | 2024-10-22: Updated project metadata. |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: embryo,Drosophila, Minibrain |
Contact List
Alexey Veraksa |
contact affiliation | University of Massachusetts Boston |
contact email | alexey.veraksa@umb.edu |
lab head | |
Alexey Veraksa |
contact affiliation | University of Massachusetts Boston |
contact email | alexey.veraksa@umb.edu |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD052378
- Label: PRIDE project
- Name: Regulation of Drosophila brain development and organ growth by the Minibrain/Rala signaling network