PXD051353

PXD051353 is an original dataset announced via ProteomeXchange.

Title	Bailixiang tea, an herbal medicine formula, co-suppresses TLR2/MAPK8 and TLR2/NF-κB signaling pathways to protect against LPS-triggered cytokine storm in mice
Description	we aimed to explore the molecular mechanism underlying its effects through blood proteomics and transcriptomics analyses. To achieve this, mice were orally administered BLX for 24 h after being treated with 5 mg/kg lipopolysaccharide (LPS). The results demonstrated that BLX effectively down-regulated the overproduction of interleukin 6 (IL-6) and tumor necrosis factor-α (TNF-α) in both the serum and lung and spleen tissues. Furthermore, BLX effectively mitigated the overproduction of monocyte chemoattractant protein-1 (MCP-1) in the serum. Histopathological observations further confirmed the significant protective effect of BLX treatment against LPS-induced lung and spleen damage. Through comprehensive multi-omics analysis, it was revealed that BLX specifically targeted and regulated TLR2/MAPK8 and LR2/NF-κB signaling pathways, which play a crucial role in the production of key cytokines.
HostingRepository	iProX
AnnounceDate	2024-04-11
AnnouncementXML	Submission_2024-04-11_00:27:54.817.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Xianyu Li
SpeciesList	scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2024-04-11 00:27:25	ID requested
⏵ 1	2024-04-11 00:27:55	announced

Dataset with its publication pending

submitter keyword: Bailixiang tea, lipopolysaccharide, cytokine storm, blood proteomics, transcriptomics, TLR2/MAPK8/NF-κB signaling pathway

Xianyu Li
contact affiliation	China Academy of Chinese Medical Sciences
contact email	phd_xianyuli@foxmail.com
lab head
Xianyu Li
contact affiliation	China Academy of Chinese Medical Sciences
contact email	phd_xianyuli@foxmail.com
dataset submitter

iProX dataset URI