PXD051206 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Defining the heterogeneous molecular landscape of lung cancer cell responses to epigenetic inhibition |
| Description | HDAC inhibitors (HDACi) have been shown to exhibit powerful anticancer activities. However, cellular responses to HDAC inhibition are heterogenous and dependent on factors such as the genetic background, metabolic state, and on-/off-target engagement of individual HDACi drugs. To determine the mechanisms that drive these heterogeneous cellular responses, we quantified proteome remodeling of HDACi-treated cell lines derived from diverse genetic backgrounds. To do this, we utilized high-throughput sample multiplexed proteomics and integrated intelligent data acquisition methods to map proteomes of five cancer cell lines in response to HDACi. We found heterogeneous genetic backgrounds of cell lines can drive divergent cellular responses to HDACi. |
| HostingRepository | PRIDE |
| AnnounceDate | 2025-11-10 |
| AnnouncementXML | Submission_2025-11-10_11:59:03.098.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Chuwei Lin |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | phosphorylated residue |
| Instrument | Orbitrap Eclipse |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2024-04-04 15:08:07 | ID requested | |
| ⏵ 1 | 2025-11-10 11:59:03 | announced | |
Publication List
| Dataset with its publication pending |
Keyword List
Contact List
| Devin Schweppe |
|---|
| contact affiliation | Genome Sciences, University of Washington, Seattle, WA |
| contact email | dkschwep@uw.edu |
| lab head | |
| Chuwei Lin |
|---|
| contact affiliation | University of Washington |
| contact email | chuweil@uw.edu |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/11/PXD051206 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD051206
- Label: PRIDE project
- Name: Defining the heterogeneous molecular landscape of lung cancer cell responses to epigenetic inhibition
