PXD050850
PXD050850 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | The Role of DNA Origami in Treating Diabetic Sepsis |
| Description | Treating diabetic sepsis (DS) can be challenging due to the persistent infection of multiple organs. To address this complicated pathological condition, it is necessary to develop advanced materials and gain a better understanding of their roles. In this study, we developed a two-dimensional planar material with a rectangular DNA origami nanostructure (termed Rec-DON). Rec-DON was used to improve liver and renal function in mice with DS due to its preferential accumulation in the kidney and liver and its superior anti-inflammatory and reactive oxygen species (ROS) scavenging activities. The role of Rec-DON in the treatment of DS in mice was investigated using quantitative proteomics. The study found that Rec-DON can regulate key proteins primarily located in the cytoplasm and mitochondrion, involved in protein transport, antigen processing and presentation, and steroid metabolic process, and performed various proteins binding to restore liver and renal function in DS mice. The study presented Rec-DON as a liver and kidney targeting material and revealed its role in alleviating multi-organ injury in DS. |
| HostingRepository | iProX |
| AnnounceDate | 2024-03-21 |
| AnnouncementXML | Submission_2024-03-20_23:45:30.406.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Yong Zhang |
| SpeciesList | scientific name: Mus musculus; NCBI TaxID: 10090; |
| ModificationList | deaminated residue |
| Instrument | Orbitrap Fusion Lumos |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2024-03-20 23:45:09 | ID requested | |
| ⏵ 1 | 2024-03-20 23:45:30 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: DNA origami, Diabetic sepsis, Proteomics, Anti-inflammatory, Reactive oxygen species. |
Contact List
| Yong Zhang | |
|---|---|
| contact affiliation | West China Hospital, Sichuan University |
| contact email | nankai1989@foxmail.com |
| lab head | |
| Yong Zhang | |
| contact affiliation | West China Hospital, Sichuan University |
| contact email | nankai1989@foxmail.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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