PXD050139

PXD050139 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Implications of O-glycan modifications in the hinge region of a plant-produced SARS-CoV-2-IgA antibody on functionality
Description	In this study, we carried out host engineering to generate a therapeutic glycoprotein largely devoid of plant-endogenous O-glycans for functional characterization. We generated four variants of a potentSARS-CoV-2 neutralizing antibody, COVA2-15 IgA1. The variants that differed in the number of modified proline residues and O-glycan compositions of their hinge region were assessed regarding their physicochemical properties and functionality.
HostingRepository	PRIDE
AnnounceDate	2024-02-27
AnnouncementXML	Submission_2024-02-27_07:29:52.888.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Richard Strasser
SpeciesList	scientific name: Nicotiana benthamiana; NCBI TaxID: 4100;
ModificationList	complex glycosylation
Instrument	Orbitrap Exploris 480

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2024-02-26 02:34:35	ID requested
⏵ 1	2024-02-27 07:29:53	announced

Publication List

Dataset with its publication pending

Dataset with its publication pending

Keyword List

submitter keyword: glycosylation, antibody,glycoprotein, Nicotiana benthamiana,virus

submitter keyword: glycosylation, antibody,glycoprotein, Nicotiana benthamiana,virus

Contact List

Richard Strasser
contact affiliation	Department of Applied Genetics and Cell Biology, University of Natural Resources and Life Sciences, Vienna, Austria
contact email	richard.strasser@boku.ac.at
lab head
Richard Strasser
contact affiliation	University of Natural Resources and Life Sciences Vienna
contact email	richard.strasser@boku.ac.at
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/02/PXD050139
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/02/PXD050139

PRIDE project URI

Repository Record List

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