PXD049700

PXD049700 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Phase separation of CTD of RNAPII
Description	The carboxy-terminal domain (CTD) of the largest subunit of RNA Polymerase II (RNAPII) consists of multiple tandem repeats of the heptapeptide consensus Y1-S2-P3-T4-S5-P6-S7. RNAPII CTD is intrinsically disordered and has been shown to promote liquid-liquid phase-separation (LLPS) of RNAPII in vivo. However, understanding the precise role of the conserved heptad residues in LLPS has been hampered by the lack of direct characterization of the biochemical properties of the CTD. Here, we generated a systematic array of RNAPII CTD variants to unravel the sequence-encoded molecular grammar underlying LLPS of the human CTD.
HostingRepository	PRIDE
AnnounceDate	2024-09-19
AnnouncementXML	Submission_2024-09-19_00:38:25.806.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Martin Mátl
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	impact II

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2024-02-19 13:00:11	ID requested
⏵ 1	2024-09-19 00:38:26	announced

Publication List

Dataset with its publication pending

Dataset with its publication pending

Keyword List

submitter keyword: RNAPII, LLPS,human

submitter keyword: RNAPII, LLPS,human

Contact List

Richard Štefl
contact affiliation	Head of Research Centre Centre for Structural Biology CEITEC MU
contact email	stefl@chemi.muni.cz
lab head
Martin Mátl
contact affiliation	Masaryk University
contact email	241757@muni.cz
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/09/PXD049700
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/09/PXD049700

PRIDE project URI

Repository Record List

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