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PXD048429

PXD048429 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleThe Small Extracellular Vesicle-Mediated Intercellular Transformation of CXCR1-Low to CXCR1-High Tumor Cells Promotes the Progression of Head and Neck Squamous Cell Carcinoma
DescriptionThe heterogeneity of tumor cells enables cancers to dynamically adapt to microenvironmental stresses during progression. However, the mechanism underlying the transformation and intercellular communication between heterogeneous tumor cells has remained elusive. Here, we report a “contagion model” that mediates intercellular transformation between heterogeneous tumor cells which facilitates tumor progression. Initially identifying heterogeneous expression of CXCR1, a receptor for interleukin-8, in head and neck squamous cell carcinoma (HNSCC) tumor cells, we found that CXCR1-High cells transformed CXCR1-Low cells into CXCR1-High cells through the secretion of small extracellular vesicles.We demonstrate that sEVs derived from interleukin-8-activated CXCR1-High cells contain high levels of ATP citrate lyase (ACLY) mediated this process.
HostingRepositoryiProX
AnnounceDate2024-01-05
AnnouncementXMLSubmission_2024-09-01_23:02:45.264.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterQiaoshi Xu
SpeciesList scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationListNo PTMs are included in the dataset
InstrumentQ Exactive Plus
Dataset History
RevisionDatetimeStatusChangeLog Entry
02024-01-10 19:11:31ID requested
12024-09-01 23:02:45announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: Small Extracellular Vesicle,CXCR1, Head and Neck Squamous Cell Carcinoma
Contact List
Zhien Feng
contact affiliationDepartment of Oral and Maxillofacial-Head and Neck Oncology, Beijing Stomatological Hospital, Capital Medical University
contact emailjyfzhen@126.com
lab head
Qiaoshi Xu
contact affiliationDepartment of Oral and Maxillofacial-Head and Neck Oncology, Beijing Stomatological Hospital, Capital Medical University
contact emailxqsgarfield@126.com
dataset submitter
Full Dataset Link List
iProX dataset URI