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PXD048369

PXD048369 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleMetabolomic Analysis of Follicular Fluid in Normal-weight Patients with PCOS (Polycystic Ovary Syndrome)
DescriptionPolycystic ovary syndrome (PCOS) is an endocrine disease with metabolic disorders, and patients with PCOS often have impaired reproductive potential. Examining the composition of follicular fluid (FF) in these patients can help identify the specific changes that may impact oocyte quality and potentially cause infertility. This study sought to examine the differential variations in the metabolic composition of FF among normal-weight patients with PCOS and controls and to identify potential biomarkers that may offer insights into the early identification and management of these patients. We collected FF samples from 45 normal-weight women with PCOS and 36 normal-weight controls without PCOS who were undergoing in vitro fertilization-embryo transfer. Untargeted metabolomic study of collected FF from infertile women was performed using high-performance liquid chromatography–tandem spectrometry (LC-MS). The tendency of the two groups to separate was demonstrated through multivariate analysis. Univariate analysis and variable importance in the projection were used to screen out differential metabolites. Metabolic pathway analysis was conducted using the Kyoto Encyclopedia of Genes and Genomes (KEGG), and a diagnostic model was established using the random forest algorithm.
HostingRepositoryiProX
AnnounceDate2024-01-09
AnnouncementXMLSubmission_2024-01-10_22:21:10.257.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterJiayue Yu
SpeciesList scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationListNo PTMs are included in the dataset
InstrumenttimsTOF Pro
Dataset History
RevisionDatetimeStatusChangeLog Entry
02024-01-09 23:17:03ID requested
12024-01-10 22:21:10announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: polycystic ovary syndrome, follicular fluid, metabolomics, LC‒MS, reproductive
Contact List
Suming Chen
contact affiliationThe Institute for Advanced Studies, Wuhan University
contact emailchensm@iccas.ac.cn
lab head
Jiayue Yu
contact affiliationReproductive Medicine Center, Renmin Hospital of Wuhan University.
contact email18883289206@163.com
dataset submitter
Full Dataset Link List
iProX dataset URI