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PXD048063

PXD048063 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleProteomics of plasma exosomes reveals S100A8 as a novel biomarker for Alzheimer’s disease: a preliminary study
DescriptionLevels of blood exosomal Aβ42, total Tau (t-Tau) and phosphorylated Tau (p-Tau) had a high correlation with their concentrations in cerebrospinal fluid (CSF), demonstrating that exosomal biomarkers have equal contribution as those in CSF for the diagnosis of AD. We aimed to comprehensively characterize the proteome of plasma exosomes to identify differentially expressed proteins (DEPs) and pathways in AD. Tandem mass tag (TMT) labeled quantitative proteomics was applied to analyze plasma exosomal proteins in 9 AD patients and 9 healthy controls.
HostingRepositoryiProX
AnnounceDate2023-12-21
AnnouncementXMLSubmission_2023-12-21_18:41:33.807.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterGuofeng Yang
SpeciesList scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationListNo PTMs are included in the dataset
InstrumentOrbitrap Fusion Lumos
Dataset History
RevisionDatetimeStatusChangeLog Entry
02023-12-21 18:40:58ID requested
12023-12-21 18:41:34announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: Alzheimer's disease, Exosomes, Proteomics, Biomarker, S100A8, siRNA
Contact List
Guofeng Yang
contact affiliationDepartment of Geriatrics, The Second Hospital of Hebei Medical University
contact emailgf_yang71@126.com
lab head
Guofeng Yang
contact affiliationDepartment of Geriatrics, The Second Hospital of Hebei Medical University
contact emailgf_yang71@126.com
dataset submitter
Full Dataset Link List
iProX dataset URI