PXD047795 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Nitrogen signaling factor triggers a respiration-like gene expression program |
Description | Microbes have evolved intricate communication systems that enable individual cells of a population to send and receive signals in response to changes in their immediate environment. In the fission yeast Schizosaccharomyces pombe, nitrogen signaling factor (NSF) is part of such communication system, which functions to regulate the usage of different nitrogen sources. Yet, the pathways and mechanisms by which NSF acts are poorly understood. Here, we show that NSF physically interacts with the mitochondrial sulfide quinone oxidoreductase Hmt2 and that it prompts a change from a fermentation- to a respiration-like gene expression program independently of the carbon source. Our results suggest that NSF activity is not restricted to nitrogen metabolism alone and that it could function as a rheostat to prepare a population of S. pombe cells for an imminent shortage of their preferred nutrients. |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-22 |
AnnouncementXML | Submission_2024-10-22_06:47:26.734.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Vytautas Iesmantavicius |
SpeciesList | scientific name: Saccharomyces cerevisiae (Baker's yeast); NCBI TaxID: 4932; |
ModificationList | monohydroxylated residue; iodoacetamide derivatized residue |
Instrument | Orbitrap Fusion Lumos |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2023-12-13 08:46:36 | ID requested | |
1 | 2024-06-25 11:11:47 | announced | |
⏵ 2 | 2024-10-22 06:47:27 | announced | 2024-10-22: Updated project metadata. |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: NSF, cell communication, nitrogen metabolism, nitrogen signaling |
Contact List
Marc Bühler |
contact affiliation | Professor in Molecular Biology & Research Group Leader, Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland |
contact email | marc.buehler@fmi.ch |
lab head | |
Vytautas Iesmantavicius |
contact affiliation | Friedrich Miescher Institute for Biomedical Research |
contact email | vytautas.iesmantavicius@fmi.ch |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/06/PXD047795 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD047795
- Label: PRIDE project
- Name: Nitrogen signaling factor triggers a respiration-like gene expression program