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PXD047795

PXD047795 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleNitrogen signaling factor triggers a respiration-like gene expression program
DescriptionMicrobes have evolved intricate communication systems that enable individual cells of a population to send and receive signals in response to changes in their immediate environment. In the fission yeast Schizosaccharomyces pombe, nitrogen signaling factor (NSF) is part of such communication system, which functions to regulate the usage of different nitrogen sources. Yet, the pathways and mechanisms by which NSF acts are poorly understood. Here, we show that NSF physically interacts with the mitochondrial sulfide quinone oxidoreductase Hmt2 and that it prompts a change from a fermentation- to a respiration-like gene expression program independently of the carbon source. Our results suggest that NSF activity is not restricted to nitrogen metabolism alone and that it could function as a rheostat to prepare a population of S. pombe cells for an imminent shortage of their preferred nutrients.
HostingRepositoryPRIDE
AnnounceDate2024-10-22
AnnouncementXMLSubmission_2024-10-22_06:47:26.734.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterVytautas Iesmantavicius
SpeciesList scientific name: Saccharomyces cerevisiae (Baker's yeast); NCBI TaxID: 4932;
ModificationListmonohydroxylated residue; iodoacetamide derivatized residue
InstrumentOrbitrap Fusion Lumos
Dataset History
RevisionDatetimeStatusChangeLog Entry
02023-12-13 08:46:36ID requested
12024-06-25 11:11:47announced
22024-10-22 06:47:27announced2024-10-22: Updated project metadata.
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: NSF, cell communication, nitrogen metabolism, nitrogen signaling
Contact List
Marc Bühler
contact affiliationProfessor in Molecular Biology & Research Group Leader, Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland
contact emailmarc.buehler@fmi.ch
lab head
Vytautas Iesmantavicius
contact affiliationFriedrich Miescher Institute for Biomedical Research
contact emailvytautas.iesmantavicius@fmi.ch
dataset submitter
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Dataset FTP location
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