PXD047631
PXD047631 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Heart proteomics of pathological atrial enlargement associated with atrial fibrillation |
| Description | Atrial fibrillation (AF) remains challenging to prevent and treat. It is associated with increased rates of heart failure, stroke and neurological decline. A key feature of AF is atrial enlargement. However, not all atrial enlargement progresses to pathology and AF. In the current study, we characterized mouse atria from a 1) pathological model (cardiac-specific transgenic (Tg) that develops dilated cardiomyopathy [DCM] and AF due to reduced protective signalling [PI3K]; DCM-dnPI3K), and a 2) physiological model (cardiac-specific Tg with an enlarged heart due to increased insulin-like growth factor 1 receptor; IGF1R). Atrial enlargement in the DCM-dnPI3K Tg, but not IGF1R Tg, was associated with atrial dysfunction, fibrosis and a heart failure gene expression pattern. Proteomics analysis identified proteins and pathways that were differentially regulated in pathological and physiological atrial enlargement, and provides a resource to study potential drug targets for AF. |
| HostingRepository | MassIVE |
| AnnounceDate | 2024-03-13 |
| AnnouncementXML | Submission_2024-03-13_03:50:29.400.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Non peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | David Greening |
| SpeciesList | scientific name: Mus musculus; common name: house mouse; NCBI TaxID: 10090; |
| ModificationList | Carbamidomethyl |
| Instrument | Q Exactive HF-X |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2023-12-07 19:24:57 | ID requested | |
| ⏵ 1 | 2024-03-13 03:50:29 | announced |
Publication List
| no publication |
Keyword List
| submitter keyword: heart, Atrial fibrillation, atrial enlargement, drug targets |
Contact List
| David Greening | |
|---|---|
| contact affiliation | Baker Heart & Diabetes Institute |
| contact email | david.greening@baker.edu.au |
| lab head | |
| David Greening | |
| contact affiliation | Baker Heart & Diabetes Institute |
| contact email | david.greening@baker.edu.au |
| dataset submitter | |
Full Dataset Link List
| MassIVE dataset URI |
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive.ucsd.edu/v06/MSV000093605/ |
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