PXD047556

PXD047556 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	SKP1A-mediated degradation of PRC2 triggers activation of Polycomb-silenced genes
Description	Polycomb group (PcG) proteins are evolutionarily conserved repressors of developmental genes. Paradoxically, the same PcG proteins also play roles in gene activation via mechanisms that are not yet fully understood. Here, to reveal the function of S-phase kinase-associated protein 1A (SKP1A), an essential factor of SCF (SKP1A/CULLIN1/F-box) ubiquitin ligases, polyubiquitinated proteins by SKP1A were prepared by pull-down assays and characterized by LC-MS/MS
HostingRepository	jPOST
AnnounceDate	2025-08-27
AnnouncementXML	Submission_2025-08-28_18:25:03.434.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yong-Woon Han
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	S-carboxamidomethyl-L-cysteine; 2-pyrrolidone-5-carboxylic acid (Glu)
Instrument	LTQ Orbitrap

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2023-12-05 21:03:37	ID requested
1	2025-08-26 17:50:54	announced
⏵ 2	2025-08-28 18:25:04	announced	2025-08-29: Updated PubMed.

Publication List

Kondo T, Ito S, Takano J, Han YW, Endo T, Kondo K, Shibata M, Kawashima Y, Sugishita H, Harachi M, Sharif J, Seita J, Ohara O, Nakayama M, Koseki H, SKP1A bound to Polycomb-silenced genes mediates degradation of PRC2 and preconditions their activation. Mol Cell, ():(2025) [pubmed]

Kondo T, Ito S, Takano J, Han YW, Endo T, Kondo K, Shibata M, Kawashima Y, Sugishita H, Harachi M, Sharif J, Seita J, Ohara O, Nakayama M, Koseki H, SKP1A bound to Polycomb-silenced genes mediates degradation of PRC2 and preconditions their activation. Mol Cell, ():(2025) [pubmed]

Keyword List

submitter keyword: Polycomb group proteins, ubiquitin-dependent proteasomal degradation system

submitter keyword: Polycomb group proteins, ubiquitin-dependent proteasomal degradation system

Contact List

Haruhiko Koseki
lab head
Yong-Woon Han
contact affiliation	Nagoya City University
dataset submitter

Full Dataset Link List

jPOST dataset URI
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jPOST dataset URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.jpostdb.org/JPST002411/