PXD047477
PXD047477 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Calciprotein particle-activated endothelial cells aggravate smooth muscle cell calcification via paracrine signalling |
| Description | Chronic kidney disease (CKD) is associated with increased cardiovascular risk, morphologically characterized by vascular calcification (VC). In CKD, high serum phosphate levels result in enhanced calcification propensity and the formation of circulating crystalline nanoaggregates (calciprotein particles, CPP2) containing calcium, phosphate and serum proteins. CPP2 can induce VC directly and this is recapitulated in vascular smooth muscle cells (VSMCs) in vitro. Under physiological conditions, vascular endothelial cells (ECs), rather than VSMCs are primarily exposed to circulating CPP2. Knowledge on the modulating effects of ECs on VC development is still in its infancy. The aim of this study was to investigate the paracrine signaling between ECs and VSMCs in CPP2-induced VC. To identify secreted soluble factors for CPP2-activated ECsthis factor, CPP2-activated ECs secretome was analyzed using mass spectrometry (LC/MS). |
| HostingRepository | iProX |
| AnnounceDate | 2023-11-30 |
| AnnouncementXML | Submission_2023-12-03_19:13:41.421.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Benoit Bernay |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | timsTOF Pro |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2023-12-03 19:13:13 | ID requested | |
| ⏵ 1 | 2023-12-03 19:13:41 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: Chronic kidney disease, calciprotein particles, endothelial cell activation, vascular smooth muscle cell dedifferentiation, vascular calcification, T-cadherin |
Contact List
| Jan-Luuk Hillebrands | |
|---|---|
| contact affiliation | Department of Pathology and Medical Biology University Medical Centre Groningen Hanzeplein 1 9713 GZ Groningen (EA10) - The Netherlands |
| contact email | j.l.hillebrands@umcg.nl |
| lab head | |
| Benoit Bernay | |
| contact affiliation | Plateforme Proteogen US EMerode CAEN Universiy France |
| contact email | benoit.bernay@unicaen.fr |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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