PXD047034
PXD047034 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Calorie restriction and rapamycin distinctly restore non-canonical ORF translation in the muscles of aging mice |
| Description | Loss of protein homeostasis is one of the hallmarks of aging. As such, interventions that restore proteostasis should slow down the aging process and improve healthspan. Two of the most broadly used anti-aging interventions that are effective in organisms from yeast to mammals are calorie restriction (CR) and rapamycin (RM) treatment. To identify the regulatory mechanisms by which these interventions improve the protein homeostasis in the muscle, we carried out ribosome footprinting in the muscle from mice aged under standard conditions, or under long-term treatment with CR or RM. We found that RM primarily remodels the translation of upstream, and CR the translation of downstream, open reading frames (ORFs). Mass spectrometry analysis reveals the expression of numerous non-canonical ORFs at the protein level. These novel peptides may represent new targets for therapies aiming to maintain muscle function and extend healthspan. |
| HostingRepository | MassIVE |
| AnnounceDate | 2024-06-03 |
| AnnouncementXML | Submission_2024-06-03_05:09:59.192.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Non peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Alex Schmidt |
| SpeciesList | scientific name: Mus musculus; common name: house mouse; NCBI TaxID: 10090; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Q Exactive HF |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2023-11-16 23:45:10 | ID requested | |
| ⏵ 1 | 2024-06-03 05:09:59 | announced |
Publication List
| no publication |
Keyword List
| submitter keyword: Translation, Read Through, Muscle, Aging |
Contact List
| Mihaela Zavolan | |
|---|---|
| contact affiliation | Biozentrum, University of Basel |
| contact email | mihaela.zavolan@unibas.ch |
| lab head | |
| Alexander Schmidt | |
| contact affiliation | Biozentrum, Universtiy of Basel, 4056 Basel, Switzerland |
| contact email | alex.schmidt@unibas.ch |
| lab head | |
| Alex Schmidt | |
| contact affiliation | University of Basel |
| contact email | alex.schmidt@unibas.ch |
| dataset submitter | |
Full Dataset Link List
| MassIVE dataset URI |
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive.ucsd.edu/v06/MSV000093414/ |
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