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PXD046198

PXD046198 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	hnRNPA1 SUMOylation promotes cold hypersensitivity in chronic inflammatory pain by stabilizing TRPA1 mRNA
Description	We show here that the up-regulation of SUMO1-conjugated protein levels in a CFA-induced inflammatory pain model enhances TRPA1 mRNA stability, ultimately leading to increased expression levels. We further demonstrate that hnRNPA1 binds to TRPA1 mRNA and its SUMOylation, up-regulated in CFA-induced inflammatory pain, contributes to stabilizing TRPA1 mRNA by accumulating hnRNPA1 in the cytoplasm.
HostingRepository	iProX
AnnounceDate	2023-10-18
AnnouncementXML	Submission_2023-10-17_20:39:10.769.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Qiao Zhang
SpeciesList	scientific name: Cricetulus griseus; NCBI TaxID: 10029;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Fusion

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2023-10-17 20:38:35	ID requested
⏵ 1	2023-10-17 20:39:11	announced

Publication List

Dataset with its publication pending

Keyword List

submitter keyword: TRPA1 mRNA, mRNA stability, RBPs

Contact List

Yong Li
contact affiliation	Shanghai Jiao Tong University School of Medicine
contact email	liyong68@shsmu.edu.cn
lab head
Qiao Zhang
contact affiliation	Shanghai Jiao Tong University School of Medicine
contact email	zhangqiao@alumni.sjtu.edu.cn
dataset submitter

Full Dataset Link List

iProX dataset URI