PXD045834

PXD045834 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	NCLX proximity biotinylation screen
Description	The mitochondrial sodium/calcium exchanger, NCLX, is critical to maintaining mitochondrial calcium homeostasis, yet little remains known about the mechanisms regulating its function. Here, we performed proximity biotinylation screening to identify the NCLX interactome and potential protein regulators of NCLX function by expressing a human NCLX-BioID2 fusion protein, or BioID2 alone, in AC16 cardiomyocytes and in HeLa cells. Biotinylated proteins were identified via affinity purification mass spectrometry.
HostingRepository	MassIVE
AnnounceDate	2025-04-02
AnnouncementXML	Submission_2025-04-02_07:45:50.431.xml
DigitalObjectIdentifier
ReviewLevel	Non peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Joanne Garbincius
SpeciesList	scientific name: Homo sapiens; common name: human; NCBI TaxID: 9606;
ModificationList	Oxidation
Instrument	Q Exactive Plus

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2023-09-29 16:38:59	ID requested
⏵ 1	2025-04-02 07:45:50	announced

Publication List

no publication

no publication

Keyword List

submitter keyword: NCLX, proximity biotinylation

submitter keyword: NCLX, proximity biotinylation

Contact List

John Elrod
contact affiliation	Lewis Katz School of Medicine at Temple University
contact email	elrod@temple.edu
lab head
Joanne Garbincius
contact affiliation	Temple University
contact email	garbincius@temple.edu
dataset submitter

Full Dataset Link List

MassIVE dataset URI
Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive-ftp.ucsd.edu/v06/MSV000093004/

MassIVE dataset URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive-ftp.ucsd.edu/v06/MSV000093004/