PXD045715 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Chemoproteomics-guided development of SLC15A4 inhibitors with anti-inflammatory activity |
Description | SLC15A4 is an endolysosome-resident transporter intimately linked with autoinflammation and autoimmunity. Specifically, SLC15A4 is critical for Toll-like receptor (TLR) 7-9 as well as the nucleotide-binding oligomerization domain-containing protein (NOD) signaling in several immune cell subsets. Notably, SLC15A4 is essential for the development of systemic lupus erythematosus in murine models and is associated with autoimmune conditions in humans. Despite its therapeutic potential, to our knowledge no chemical probes have been developed that target SLC15A4. Here, we use an integrated chemical proteomics approach to develop a suite of chemical tools, including first-in-class functional inhibitors, for SLC15A4. We demonstrate SLC15A4 inhibitors described herein suppress endolysosomal TLR and NOD functions in a variety of human and mouse immune cells, furnish evidence of their ability to suppress inflammation in vivo and in clinical settings, and provide insights into their mechanism of action. Our findings establish SLC15A4 as a druggable target for the treatment of autoimmune/autoinflammatory conditions. |
HostingRepository | PRIDE |
AnnounceDate | 2023-11-30 |
AnnouncementXML | Submission_2023-11-29_17:17:30.854.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Weichao Li |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | No PTMs are included in the dataset |
Instrument | Orbitrap Fusion Lumos; Orbitrap Fusion |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2023-09-26 16:38:16 | ID requested | |
⏵ 1 | 2023-11-29 17:17:31 | announced | |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: Chemoproteomic, anti-inflammatory,SLC15A4 |
Contact List
Christopher Parker |
contact affiliation | Scripps Research |
contact email | cparker@scripps.edu |
lab head | |
Weichao Li |
contact affiliation | The Scripps Research Institute |
contact email | wli@scripps.edu |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/11/PXD045715 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD045715
- Label: PRIDE project
- Name: Chemoproteomics-guided development of SLC15A4 inhibitors with anti-inflammatory activity