PXD045652

PXD045652 is an original dataset announced via ProteomeXchange.

Title	BDNF-TrkB signaling orchestrates the buildup process for local sleep
Description	Using pharmacology and optogenetics perturbations, we showed that cortical brain-derived neurotrophic factor (BDNF) regulates the intensity of SWA via the activation of Tyrosine kinase B (TrkB) receptor and cAMP-response element-binding protein (CREB). We identified that the circuitry mediating TrkB-induced sleep SWA involves excitatory pyramidal cells of the cortex's layer 5. We found that increased neuronal firing alone in the somatosensory cortex was not sufficient to increase SWA. Using mathematical modeling of a local network in the brain, we model how BDNF’s effects on synaptic strength can increase SWA in ways not achieved through increased firing alone. Together, our findings implicate BDNF-TrkB-CREB signaling pathway in local SWA control during sleep.
HostingRepository	PRIDE
AnnounceDate	2024-06-22
AnnouncementXML	Submission_2024-06-22_06:10:12.625.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Fabian Kliem
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	iodoacetamide derivatized residue
Instrument	Orbitrap Exploris 480

Revision	Datetime	Status	ChangeLog Entry
0	2023-09-25 06:32:18	ID requested
⏵ 1	2024-06-22 06:10:12	announced

Dataset with its publication pending

submitter keyword: circadian,BDNF, Sleep homeostasis, CREB, TrkB, Local sleep

Maria Robles
contact affiliation	System Chronobiology Institute for Medical Psychology Ludwig-Maximilians-Universität München Germany
contact email	charo.robles@med.uni-muenchen.de
lab head
Fabian Kliem
contact affiliation	Ludwigs Maximilians Universität
contact email	kliemfabian@googlemail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/06/PXD045652

PRIDE project URI

• PRIDE
  1. PXD045652
     1. Label: PRIDE project
     2. Name: BDNF-TrkB signaling orchestrates the buildup process for local sleep