PXD045561 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Cathepsin B Promotes Aβ Proteotoxicity by Modulating Aging Regulating Mechanisms |
Description | While the activities of certain proteases promote proteostasis and prevent neurodegeneration-associated phenotypes, the protease cathepsin B (CTSB) enhances proteotoxicity in Alzheimer’s disease (AD) model mice, and its levels are elevated in brains of AD patients. How CTSB exacerbates the toxicity of the AD causing Amyloid β (Aβ), is controversial. Using an activity-based probe, aging-altering interventions and the nematode C. elegans we discovered that the CTSB CPR-6 promotes Aβ proteotoxicity but mitigates the toxicity of polyQ stretches. While the knockdown of cpr-6 does not affect lifespan, it alleviates Aβ toxicity by reducing the expression of swsn-3 and elevating the level of the protein SMK-1, both involved in the regulation of aging. These observations unveil a novel mechanism by which CTSB aggravates Aβ– mediated toxicity, indicate that it plays opposing roles in the face of distinct proteotoxic insults and highlight the importance of tailoring specific remedies for distinct neurodegenerative disorders. |
HostingRepository | PRIDE |
AnnounceDate | 2024-09-04 |
AnnouncementXML | Submission_2024-09-13_11:56:45.554.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Yong-hong Yan |
SpeciesList | scientific name: Caenorhabditis elegans; NCBI TaxID: 6239; |
ModificationList | No PTMs are included in the dataset |
Instrument | Q Exactive HF |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2023-09-21 06:40:59 | ID requested | |
⏵ 1 | 2024-09-13 11:56:45 | announced | |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: Cathepsin B ,C. elegans,Aβ Proteotoxicity |
Contact List
Meng-Qiu Dong |
contact affiliation | National Institute of Biological Sciences, Beijing |
contact email | dongmengqiu@nibs.ac.cn |
lab head | |
Yong-hong Yan |
contact affiliation | National Institute of Biological Sciences, Beijing |
contact email | yanyonghong@nibs.ac.cn |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD045561
- Label: PRIDE project
- Name: Cathepsin B Promotes Aβ Proteotoxicity by Modulating Aging Regulating Mechanisms