PXD045503
PXD045503 is an original dataset announced via ProteomeXchange.
Dataset Summary
Title | YBX1 promotes homologous recombination and resistance to platinum-induced stress in ovarian cancer by recognizing m5C modification |
Description | Platinum-based chemotherapy causes genetic damage and induces apoptosis in ovarian cancer cells. Enhancing the ability to resist platinum drug-induced DNA damage and apoptotic stress is critical for tumor cells to acquire drug resistance. Here, we found that Y-box binding protein 1 (YBX1) was highly expressed in platinum-resistant patient-derived organoids (PDOs) and was a crucial gene for alleviating platinum-induced stress and maintaining drug resistance characteristics in ovarian cancer cells. |
HostingRepository | iProX |
AnnounceDate | 2023-09-19 |
AnnouncementXML | Submission_2025-06-03_20:03:03.626.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Wenjun Cheng |
SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
ModificationList | No PTMs are included in the dataset |
Instrument | Q Exactive |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
---|---|---|---|
0 | 2023-09-19 19:46:38 | ID requested | |
⏵ 1 | 2025-06-03 20:03:04 | announced |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: YBX1 |
Contact List
Wenjun Cheng | |
---|---|
contact affiliation | The First Affiliated Hospital of Nanjing Medical University, Nanjing, China. |
contact email | chengwenjun@jsph.org.cn |
lab head | |
Wenjun Cheng | |
contact affiliation | The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu, China |
contact email | chengwenjun@jsph.org.cn |
dataset submitter |
Full Dataset Link List
iProX dataset URI |