PXD045194

PXD045194 is an original dataset announced via ProteomeXchange.

Title	Targeting metabolic fluxes reverts metastatic transitions in ovarian cancer
Description	Spheroid formation during epithelial ovarian cancer progression correlates with peritoneal organ colonization, disease recurrence, and poor prognosis. Although cancer progression has been demonstrated to be associated with and driven by metabolic changes within transformed cells, possible associations between metabolic dynamics and metastatic morphological transitions remain unexplored. To address this problem, performed quantitative proteomics was performed to identify protein signatures associated with three distinct morphologies (2D monolayers and two geometrically individual three-dimensional spheroidal states) of the high-grade serous ovarian cancer line OVCAR-3. Integrating the protein states into genome-scale metabolic models allowed the construction of context-specific metabolic models for each morphological stage of the OVCAR-3 cell line and systematically evaluate their metabolic functionalities.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_06:02:47.761.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	gagan jhingan
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2023-09-07 07:17:17	ID requested
1	2023-09-07 07:39:24	announced
⏵ 2	2024-10-22 06:02:48	announced	2024-10-22: Updated project metadata.

Dataset with its publication pending

submitter keyword: OVCAR-3, ovarian cancer,Genome-scale metabolic models, oseltamivir, morphological transitions, drug repurposing

Prof. Ramray Bhat
contact affiliation	Associate Professor, Centre for Biosystems Science and Engineering, IISC Bangalore, India
contact email	ramray@iisc.ac.in
lab head
gagan jhingan
contact affiliation	VProteomics
contact email	gaganjhingan@hotmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/09/PXD045194

PRIDE project URI

• PRIDE
  1. PXD045194
     1. Label: PRIDE project
     2. Name: Targeting metabolic fluxes reverts metastatic transitions in ovarian cancer