PXD044915 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Ustilago maydis PR-1-like protein has evolved two distinct domains for dual virulence activities |
Description | Diversification of effector function, driven by a co-evolutionary arms race, enables pathogens to establish compatible interactions with hosts. Structurally conserved plant pathogenesis-related PR-1 and PR-1-like (PR-1L) proteins are involved in plant defense and fungal virulence, respectively. It is unclear how fungal PR-1L counters plant defense. Here, we show that Ustilago maydis UmPR-1La and yeast ScPRY1, with conserved phenolic resistance functions, are Ser/Thr-rich region-mediated cell-surface localization proteins. However, UmPR-1La has gained specialized activity in sensing phenolics and eliciting hyphal-like formation to guide fungal growth in plants. Additionally, U. maydis hijacks maize cathepsin B-like 3 (CatB3) to release functional CAPE-like peptides by cleaving UmPR-1La’s conserved CNYD motif, subverting plant CAPE-primed immunity and promoting fungal virulence. Surprisingly, CatB3 avoids cleavage of plant PR-1s, despite the presence of the same conserved CNYD motif. Our work highlights that UmPR-1La has acquired additional dual roles to suppress plant defense and sustain the infection process of fungal pathogens. |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-22 |
AnnouncementXML | Submission_2024-10-22_06:02:03.461.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Chuan-Chih Hsu |
SpeciesList | scientific name: Ustilago maydis (Smut fungus); NCBI TaxID: 5270; |
ModificationList | No PTMs are included in the dataset |
Instrument | Q Exactive |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2023-08-28 19:45:19 | ID requested | |
1 | 2023-08-28 20:02:05 | announced | |
⏵ 2 | 2024-10-22 06:02:03 | announced | 2024-10-22: Updated project metadata. |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: Ustilago maydis, CAPE-like, fungal virulence, Cathepsin B-like 3, PRY1, phenolic resistance, PR-1-like, CNYD motif |
Contact List
Lay-Sun Ma |
contact affiliation | Institute of Plant and Microbial Biology, Academia Sinica |
contact email | laysunma@gate.sinica.edu.tw |
lab head | |
Chuan-Chih Hsu |
contact affiliation | Academia Sinica |
contact email | without1102@gmail.com |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD044915
- Label: PRIDE project
- Name: Ustilago maydis PR-1-like protein has evolved two distinct domains for dual virulence activities