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PXD044915

PXD044915 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleUstilago maydis PR-1-like protein has evolved two distinct domains for dual virulence activities
DescriptionDiversification of effector function, driven by a co-evolutionary arms race, enables pathogens to establish compatible interactions with hosts. Structurally conserved plant pathogenesis-related PR-1 and PR-1-like (PR-1L) proteins are involved in plant defense and fungal virulence, respectively. It is unclear how fungal PR-1L counters plant defense. Here, we show that Ustilago maydis UmPR-1La and yeast ScPRY1, with conserved phenolic resistance functions, are Ser/Thr-rich region-mediated cell-surface localization proteins. However, UmPR-1La has gained specialized activity in sensing phenolics and eliciting hyphal-like formation to guide fungal growth in plants. Additionally, U. maydis hijacks maize cathepsin B-like 3 (CatB3) to release functional CAPE-like peptides by cleaving UmPR-1La’s conserved CNYD motif, subverting plant CAPE-primed immunity and promoting fungal virulence. Surprisingly, CatB3 avoids cleavage of plant PR-1s, despite the presence of the same conserved CNYD motif. Our work highlights that UmPR-1La has acquired additional dual roles to suppress plant defense and sustain the infection process of fungal pathogens.
HostingRepositoryPRIDE
AnnounceDate2024-10-22
AnnouncementXMLSubmission_2024-10-22_06:02:03.461.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterChuan-Chih Hsu
SpeciesList scientific name: Ustilago maydis (Smut fungus); NCBI TaxID: 5270;
ModificationListNo PTMs are included in the dataset
InstrumentQ Exactive
Dataset History
RevisionDatetimeStatusChangeLog Entry
02023-08-28 19:45:19ID requested
12023-08-28 20:02:05announced
22024-10-22 06:02:03announced2024-10-22: Updated project metadata.
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: Ustilago maydis, CAPE-like, fungal virulence, Cathepsin B-like 3, PRY1, phenolic resistance, PR-1-like, CNYD motif
Contact List
Lay-Sun Ma
contact affiliationInstitute of Plant and Microbial Biology, Academia Sinica
contact emaillaysunma@gate.sinica.edu.tw
lab head
Chuan-Chih Hsu
contact affiliationAcademia Sinica
contact emailwithout1102@gmail.com
dataset submitter
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Dataset FTP location
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