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PXD044911

PXD044911 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitlepH-gated nanoparticles selectively regulate lysosomal function of tumour-associated macrophages for cancer immunotherapy
DescriptionTumour-associated macrophages (TAMs), as one of the most abundant and phagocytic tumour-infiltrating immune cells, play a pivotal role in tumour antigen clearance and immune suppression. M2-like TAMs present a heightened lysosomal acidity and protease activity, which limits the function of antigen cross-presentation. How to selectively reprogram the antigen-destroying TAMs to a restorative phenotype for efficient anti-tumour immunity is challenging. Here, we report a pH-gated nanoadjuvant (PGN) that selectively targets the lysosomes of M2-like TAMs in tumours rather than the corresponding organelles from macrophages in healthy tissues. Enabled by the PGN nanotechnology, M2-like TAMs are specifically switched to M1-like phenotypes with tuned-down lysosomal function featured by attenuated lysosomal acidity and cathepsin activity for improved antigen cross-presentation, thus provoking adaptive immune response and sustained tumour regression. Our findings provide new insights into how to specifically regulate lysosomal function of TAMs for efficient cancer immunotherapy.
HostingRepositoryPRIDE
AnnounceDate2023-08-29
AnnouncementXMLSubmission_2023-08-28_17:28:35.838.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterTangMingmei
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationListNo PTMs are included in the dataset
InstrumentQ Exactive
Dataset History
RevisionDatetimeStatusChangeLog Entry
02023-08-28 09:10:27ID requested
12023-08-28 17:28:36announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: tumour-associated macrophages
Contact List
Tangmingmei
contact affiliationWang Yiguang lab
contact emailmingmeitang@bjmu.edu.cn
lab head
TangMingmei
contact affiliationPeking University
contact emailmingmeitang@bjmu.edu.cn
dataset submitter
Full Dataset Link List
Dataset FTP location
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