PXD044911 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | pH-gated nanoparticles selectively regulate lysosomal function of tumour-associated macrophages for cancer immunotherapy |
Description | Tumour-associated macrophages (TAMs), as one of the most abundant and phagocytic tumour-infiltrating immune cells, play a pivotal role in tumour antigen clearance and immune suppression. M2-like TAMs present a heightened lysosomal acidity and protease activity, which limits the function of antigen cross-presentation. How to selectively reprogram the antigen-destroying TAMs to a restorative phenotype for efficient anti-tumour immunity is challenging. Here, we report a pH-gated nanoadjuvant (PGN) that selectively targets the lysosomes of M2-like TAMs in tumours rather than the corresponding organelles from macrophages in healthy tissues. Enabled by the PGN nanotechnology, M2-like TAMs are specifically switched to M1-like phenotypes with tuned-down lysosomal function featured by attenuated lysosomal acidity and cathepsin activity for improved antigen cross-presentation, thus provoking adaptive immune response and sustained tumour regression. Our findings provide new insights into how to specifically regulate lysosomal function of TAMs for efficient cancer immunotherapy. |
HostingRepository | PRIDE |
AnnounceDate | 2023-08-29 |
AnnouncementXML | Submission_2023-08-28_17:28:35.838.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | TangMingmei |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
ModificationList | No PTMs are included in the dataset |
Instrument | Q Exactive |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2023-08-28 09:10:27 | ID requested | |
⏵ 1 | 2023-08-28 17:28:36 | announced | |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: tumour-associated macrophages |
Contact List
Tangmingmei |
contact affiliation | Wang Yiguang lab |
contact email | mingmeitang@bjmu.edu.cn |
lab head | |
TangMingmei |
contact affiliation | Peking University |
contact email | mingmeitang@bjmu.edu.cn |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD044911
- Label: PRIDE project
- Name: pH-gated nanoparticles selectively regulate lysosomal function of tumour-associated macrophages for cancer immunotherapy