PXD044682 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Phosphoproteomic Landscape of Pseudorabies Virus Infection Reveals Multiple Potential Antiviral Targets |
Description | A quantitative phosphoproteome was conducted to explore the phosphorylation changes and host cellular responses upon PRV infection. Besides, the characteristics of the phosphorylated proteins were analyzed, including molecular distribution, percentage of the phosphorylated (STY) sites, and phosphorylated motifs. Additionally, the GO and KEGG analyses of the significantly changed phophoproteins were performed. Finally, DNMT1, HDAC6, EGFR, GRK2, VIM, and G3BP1 were chosen for analysis of their effect on PRV replication using an inhibitory-based experiment, and the results showed that all these proteins are necessary for efficient PRV replication. |
HostingRepository | PRIDE |
AnnounceDate | 2023-11-17 |
AnnouncementXML | Submission_2023-11-16_17:33:27.733.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Zongyi Bo |
SpeciesList | scientific name: Sus scrofa domesticus (domestic pig); NCBI TaxID: 9825; |
ModificationList | phosphorylated residue |
Instrument | Q Exactive HF |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2023-08-21 01:37:48 | ID requested | |
⏵ 1 | 2023-11-16 17:33:28 | announced | |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: phosphoproteomic landscape,Pseudorabies Virus, antiviral targets, virus-host interaction |
Contact List
Zongyi Bo |
contact affiliation | Yangzhou university |
contact email | zybo@yzu.edu.cn |
lab head | |
Zongyi Bo |
contact affiliation | Yangzhou agriculture university |
contact email | zybo@yzu.edu.cn |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD044682
- Label: PRIDE project
- Name: Phosphoproteomic Landscape of Pseudorabies Virus Infection Reveals Multiple Potential Antiviral Targets