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PXD044642

PXD044642 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleDevelopment of pathophysiologically relevant models of sickle cell disease and β-thalassemia for therapeutic studies
Descriptionβ-hemoglobin disorders, such as sickle cell disease (SCD) and β-thalassemia (BT), are the most common inherited monogenic blood disorders globally. Despite decades of research, there are only four FDA-approved medications available for the management of SCD with hydroxyurea (HU) being the most widely used drug that partially benefits patients by inducing fetal hemoglobin (HbF) production. On the other hand, there are no approved oral drugs currently available for β-thalassemia patients. To our knowledge, there are currently no well-characterized erythroid progenitor cell lines available that can accurately replicate the pathophysiology of SCD and BT while also having the same genetic background apart from the disease mutation enabling consistency and reproducibility. Our novel, physiologically relevant cellular systems provide a plethora of avenues for researchers to investigate various applications related to parasite invasion, drug validation, and genome-editing in the context of SCD and BT.
HostingRepositoryPRIDE
AnnounceDate2024-02-07
AnnouncementXMLSubmission_2024-02-07_01:03:39.254.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterSivaprakash Ramalingam
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListmonohydroxylated residue; iodoacetamide derivatized residue
InstrumentOrbitrap Fusion
Dataset History
RevisionDatetimeStatusChangeLog Entry
02023-08-18 08:35:52ID requested
12024-02-07 01:03:39announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: proteomics, mass spectrometer, sickle cell disease, Erythroid progenitor line, CRISPR/Cas9, 10-plex TMT label,β-thalassemia
Contact List
Sivaprakash Ramalingam
contact affiliationCSIR-Institute of Genomics and Integrative Biology, New Delhi
contact emailsivaramalingam@igib.res.in
lab head
Sivaprakash Ramalingam
contact affiliationCSIR-Insitute of Genomics and Integrative Biology, New Delhi
contact emailsivaramalingam@igib.res.in
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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