PXD044485
PXD044485 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Breakdown of neuronal glycogen protects against tauopathy by reducing oxidative stress |
| Description | The abnormal presence of Microtubule-associated protein Tau (MAPT) has been documented in pathologically linked diseases, including Alzheimer's disease, frontotemporal dementia and other neurodegenerative conditions collectively referred to as tauopathies. We demonstrated that dietary restriction (DR) a robust intervention for lifespan extension and neuroprotection, significantly reduces pathology in a Drosophila melanogaster model of Tauopathy overexpressing a mutant form of human tau. We showed that DR promotes neuroprotection by promoting the breakdown of glycogen. We observed impaired glycogen metabolism in fly and human models of tauopathy, where breakdown of neuronal glycogen occured by activating glycogen phosphorylase (GlyP) reversed Tauopathy phenotypes. Surprisingly, glycogen catabolism in neurons redirects flux to increase the pentose phosphate pathway instead of glycolysis, mitigating oxidative stress. We showed that DR activates GlyP via the cAMP-mediated protein kinase A pathway and pharmacological activation of this pathway mitigated tau pathology, suggesting a potential therapeutic intervention for managing Tauopathy. |
| HostingRepository | MassIVE |
| AnnounceDate | 2025-04-25 |
| AnnouncementXML | Submission_2025-04-25_07:03:36.412.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Non peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Jordan Burton |
| SpeciesList | scientific name: Drosophila melanogaster; common name: fruit fly; NCBI TaxID: 7227; |
| ModificationList | Acetyl; Amidated; Amino; Arg; Arg->GluSA; Arg-loss; Dehydrated; Delta:H(2)C(2); deoxygenated residue; Formyl; Oxidation; Trimethyl; Deamidated; Ammonia-loss; Pyridylacetyl; Lys-loss |
| Instrument | TripleTOF 6600 |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2023-08-10 11:17:32 | ID requested | |
| ⏵ 1 | 2025-04-25 07:03:36 | announced |
Publication List
| no publication |
Keyword List
| submitter keyword: Tauopathy, dietary restriction, glycogen, glycogenolysis, neurodegeneration, oxidative stress, cAMP, therapeutic intervention. |
Contact List
| Lisa Ellerby | |
|---|---|
| contact affiliation | Buck Institute for Research on Aging |
| contact email | lellerby@buckinstitute.org |
| lab head | |
| Birgit Schilling | |
| contact affiliation | Buck Institute |
| contact email | bschilling@buckinstitute.org |
| lab head | |
| Pankaj Kapahi | |
| contact affiliation | Buck Institute for Research on Aging |
| contact email | pkapahi@buckinstitute.org |
| lab head | |
| Jordan Burton | |
| contact affiliation | Buck Institute for Research on Aging |
| contact email | jburton@buckinstitute.org |
| dataset submitter | |
Full Dataset Link List
| MassIVE dataset URI |
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive-ftp.ucsd.edu/v06/MSV000092637/ |
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