PXD044190 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | A phylogenetic approach to explore the Aspergillus fumigatus conidial surfome and its role in pathogenesis |
Description | Aspergillus fumigatus is the most important pulmonary fungal pathogen and is able to cause several diseases collectively called aspergillosis. Conidia is the most important infection structure making the initial contact with the human host. Here, we used a phylogenomic approach comparing proteins present in the A. fumigatus conidial surface, two closely related non-pathogenic species A. fischeri and A. oerlinghausenensis, and the far-related pathogenic A. lentulus. We were able to identify 62 proteins specifically expressed on A. fumigatus conidial surface. We deleted 42 of the encoding-genes and observed that many of them have altered susceptibility to macrophage killing, penetration and damage to epithelial cells, and cytokine production. We demonstrated that one of these genes encoding a glycosylasparaginase is modulating IL-1β levels and is important for the infection in an immunocompetent murine model. Our results provide opportunities for characterizing A. fumigatus effectors important for evasion and modulation of the immune response. |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-22 |
AnnouncementXML | Submission_2024-10-22_06:47:31.682.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Giuseppe Palmisano |
SpeciesList | scientific name: Fungi; NCBI TaxID: NCBITaxon:4751; scientific name: Neosartorya fumigata (Aspergillus fumigatus); NCBI TaxID: 746128; scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | deamidated residue |
Instrument | LTQ Orbitrap |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2023-07-28 11:03:08 | ID requested | |
1 | 2024-06-26 13:02:30 | announced | |
⏵ 2 | 2024-10-22 06:47:32 | announced | 2024-10-22: Updated project metadata. |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: conidia, glycosylasparaginase, macrophages,Aspergillus fumigatus |
Contact List
Giuseppe Palmisano |
contact affiliation | University of Sao Paulo |
contact email | palmisano.gp@gmail.com |
lab head | |
Giuseppe Palmisano |
contact affiliation | University of Sao Paulo |
contact email | palmisano.gp@gmail.com |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD044190
- Label: PRIDE project
- Name: A phylogenetic approach to explore the Aspergillus fumigatus conidial surfome and its role in pathogenesis