PXD043601

PXD043601 is an original dataset announced via ProteomeXchange.

Title	Prdm16 mutation determines sex-specific cardiac metabolism and identifies two novel cardiac metabolic regulators
Description	Mutation of the PRDM16 gene causes human dilated and noncompaction cardiomyopathy. The PRDM16 protein is a transcriptional regulator that affects cardiac development via Tbx5 and Hand1, thus regulating myocardial structure. The biallelic inactivation of Prdm16 induces severe cardiac dysfunction with postnatal lethality and hypertrophy in mice. The early pathological events that occur upon Prdm16 inactivation have not been explored. This study performed in-depth pathophysiological and molecular analyses of male and female Prdm16csp1/wt mice that carry systemic, monoallelic Prdm16 gene inactivation. We systematically assessed early molecular changes through transcriptomics, proteomics, and metabolomics. Kinetic modelling of cardiac metabolism was performed in silico with CARDIOKIN.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_05:57:19.252.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Marieluise Kirchner
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	acetylated residue; monohydroxylated residue; deamidated residue; iodoacetamide derivatized residue
Instrument	Q Exactive HF-X

Revision	Datetime	Status	ChangeLog Entry
0	2023-07-07 02:44:01	ID requested
1	2023-07-21 05:05:30	announced
⏵ 2	2024-10-22 05:57:19	announced	2024-10-22: Updated project metadata.

Dataset with its publication pending

submitter keyword: mouse, heart, cardiac metabolism, cardiomyopathy

Philipp Mertins
contact affiliation	Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association, Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Proteomics Platform, Berlin, Germany
contact email	philipp.mertins@mdc-berlin.de
lab head
Marieluise Kirchner
contact affiliation	Proteomics Platform, BIH@Charite
contact email	marieluise.kirchner@mdc-berlin.de
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD043601
     1. Label: PRIDE project
     2. Name: Prdm16 mutation determines sex-specific cardiac metabolism and identifies two novel cardiac metabolic regulators