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PXD043190

PXD043190 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleLight regulates nuclear detainment of intron-retained transcripts through COP1-spliceosome to modulate photomorphogenesis
DescriptionIntron retention (IR) is the most common alternative splicing (AS) event in Arabidopsis. Increasing studies have demonstrated a major role of IR in gene expression regulation. The impacts of IR on plant growth and development, and response to environments remains under explored. Here, we found that IR functions directly in gene expression regulation on a genome-wide scale through detainment of the intron-retained transcripts (IRTs) in the nucleus. Through this mechanism, nuclear-retained IRTs can be kept away from translation. COP1-dependent light modulation of IRTs of light signaling genes, such as PIF4, RVE1, and ABA3, contribute to seedling morphological development in responding to changing light conditions. Further, light-induced IR changes are under the control of the spliceosome, and in part through COP1-dependent ubiquitination and degradation of DCS1, a plant-specific spliceosomal component. Our data suggests that light regulates the activity of the spliceosome and the consequent IRTs nucleus detainment to modulate photomorphogenesis through COP1.
HostingRepositoryPRIDE
AnnounceDate2024-10-22
AnnouncementXMLSubmission_2024-10-22_06:39:40.083.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterHua Zhou
SpeciesList scientific name: Arabidopsis thaliana (Mouse-ear cress); NCBI TaxID: 3702;
ModificationListNo PTMs are included in the dataset
InstrumentOrbitrap Fusion
Dataset History
RevisionDatetimeStatusChangeLog Entry
02023-06-21 20:57:44ID requested
12024-05-20 01:01:23announced
22024-10-22 06:39:40announced2024-10-22: Updated project metadata.
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: DCS proteins,Arabidopsis, spliceosome, COP1
Contact List
Xing Wang
contact affiliationSouthern University of Science and Technology
contact emaildeng@pku.edu.cn
lab head
Hua Zhou
contact affiliationSouthern University of Science and Technology
contact email0518226zh@163.com
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
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