PXD042262
PXD042262 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Systems level analyses of protein-protein interaction network dysfunctions via epichaperomics identify cancer-specific mechanisms of stress adaptation |
| Description | There is a penury of regents and methods that enable the identification, analysis, and modulation of context-specific protein-protein interaction (PPI) network dysfunctions in native (unengineered) cells and tissues. Herein, we take advantage of first-in-class chemical binders of maladaptive scaffolding structures termed epichaperomes and develop an epichaperome-based ‘omics platform, epichaperomics, to identify PPI alterations in disease. We provide multiple lines of evidence, at both biochemical and functional levels, demonstrating the importance of these probes to identify and study PPI network dysfunctions and provide mechanistically and therapeutically relevant proteome-wide insights. As proof-of-principle, we derive systems level insight into PPI dysfunctions of cancer cells which enabled the discovery of a context-dependent mechanism by which cancer cells enhance the fitness of mitotic protein networks. Importantly, our systems levels analyses support the use of epichaperome chemical binders as therapeutic strategies aimed at normalizing PPI networks |
| HostingRepository | MassIVE |
| AnnounceDate | 2023-05-16 |
| AnnouncementXML | Submission_2023-05-16_07:50:28.276.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Non peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Supported dataset by repository |
| PrimarySubmitter | Hediye Erdjument-Bromage |
| SpeciesList | scientific name: Homo sapiens; common name: human; NCBI TaxID: 9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Q Exactive; Q Exactive HF |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2023-05-16 07:48:35 | ID requested | |
| ⏵ 1 | 2023-05-16 07:50:28 | announced |
Publication List
| no publication |
Keyword List
| submitter keyword: Epichaperome, protein-protein interactions, cancer proteomics |
Contact List
| Dr. Thomas A. Neubert | |
|---|---|
| contact affiliation | New York University School of Medicine |
| contact email | Thomas.Neubert@med.nyu.edu |
| lab head | |
| Dr. Gabriela Chiosis | |
| contact affiliation | Memorial Sloan Kettering Cancer Center |
| contact email | chiosisg@mskcc.org |
| lab head | |
| Hediye Erdjument-Bromage | |
| contact affiliation | NYU School of Medicine |
| contact email | hediye.bromage@med.nyu.edu |
| dataset submitter | |
Full Dataset Link List
| MassIVE dataset URI |
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive.ucsd.edu/MSV000087540/ |
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