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PXD041862

PXD041862 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleIntegrative analysis reveals a conserved role for the amyloid precursor protein in proteostasis during aging
DescriptionAβ peptides derived from the amyloid precursor protein (APP) have been strongly implicated in the pathogenesis of Alzheimer’s disease. However, the normal function of APP and the importance of that role in neurodegenerative disease is less clear. We recovered the Drosophila ortholog of APP, Appl, in an unbiased forward genetic screen for neurodegeneration mutants. We performed comprehensive single cell transcriptional and proteomic studies of Appl mutant flies to investigate Appl function in the aging brain.
HostingRepositoryPRIDE
AnnounceDate2023-10-04
AnnouncementXMLSubmission_2023-10-04_08:53:08.439.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterVanithaNithianandam
SpeciesList scientific name: Drosophila melanogaster (Fruit fly); NCBI TaxID: 7227;
ModificationListubiquitination signature dipeptidyl lysine
InstrumentOrbitrap Eclipse
Dataset History
RevisionDatetimeStatusChangeLog Entry
02023-04-27 16:22:35ID requested
12023-10-04 08:53:08announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: proteomics, ubiquitinomics, amyloid precursor protein like, Appl,Drosophila melanogaster
Contact List
Mel B.Feany
contact affiliationMel Feany, M.D., Ph.D. Department of Pathology Harvard Medical School Brigham and Women's Hospital Harvard New Research Building, Room 630 77 Avenue Louis Pasteur Boston, MA 02115
contact emailmel_feany@hms.harvard.edu
lab head
VanithaNithianandam
contact affiliationBrigham and Women's Hospital, Harvard Medical School
contact emailvnithianandam@bwh.harvard.edu
dataset submitter
Full Dataset Link List
Dataset FTP location
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