PXD041689 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Fibrotic Response to anti-CSF-1R Treatment Potentiates Glioblastoma Recurrence |
Description | Treatment of glioblastoma with anti-CSF-1R immunotherapy, radiotherapy, or surgical tumor resection were found to all induce a fibrotic response to treatment, which was highly associated with tumor recurrence. To investigate the drivers of fibrotic treatment response we performed multi-omic analysis of the glioblastoma microenvironment following treatment with anti-CSF-1R immunotherapy. Studies consisted of mass spectrometry proteomic analysis, single cell transcriptomics, and high-dimensional spatial analysis. These data identified a protective spatial niche that supported tumor cell survival following treatment, ultimately leading to tumor recurrence. Therapeutic inhibition of fibrotic treatment response blocked the formation of this niche, and significantly improved survival in anti-CSF-1R preclinical trials |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-22 |
AnnouncementXML | Submission_2024-10-22_06:54:42.492.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Manfredo Quadroni |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
ModificationList | acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue |
Instrument | Orbitrap Fusion |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2023-04-20 09:05:31 | ID requested | |
1 | 2024-08-12 04:08:50 | announced | |
⏵ 2 | 2024-10-22 06:54:42 | announced | 2024-10-22: Updated project metadata. |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: multi-omic, recurrence,Glioblastoma, fibrosis, immunotherapy |
Contact List
Johanna Joyce |
contact affiliation | Department of Oncology, University of Lausanne, Lausanne, Switzerland |
contact email | johanna.joyce@unil.ch |
lab head | |
Manfredo Quadroni |
contact affiliation | University of Lausanne |
contact email | manfredo.quadroni@unil.ch |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD041689
- Label: PRIDE project
- Name: Fibrotic Response to anti-CSF-1R Treatment Potentiates Glioblastoma Recurrence