PXD041005 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Proteomic-based computational stratification of intermediate-risk prostate cancer patients. |
Description | Gleason grading is an important prognostic indicator for prostate adenocarcinoma and is crucial for patient treatment decisions. However, intermediate-risk patients diagnosed in Gleason Grade Groups (GG) 2 and GG3 can harbour either aggressive or non-aggressive disease, resulting in under- or over-treatment of a significant number of patients. Here, we performed proteomic, differential expression, machine learning, and survival analyses for 1,348 matched tumour and benign samples from 278 patients. Three proteins (F5, TMEM126B and EARS2) were identified as candidate biomarkers in patients with biochemical recurrence. Multivariate Cox regression yielded 18 proteins, from which a risk score was constructed to dichotomise prostate cancer patients into low- and high-risk groups. This 18-protein signature is prognostic for the risk of biochemical recurrence and completely independent of the intermediate GG. Our results suggest that markers generated by computational proteomic profiling have the potential for clinical applications including integration into prostate cancer management. |
HostingRepository | PRIDE |
AnnounceDate | 2023-12-04 |
AnnouncementXML | Submission_2023-12-03_21:21:55.424.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Zainab Noor |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | iodoacetamide derivatized residue |
Instrument | TripleTOF 6600 |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2023-03-21 07:07:02 | ID requested | |
⏵ 1 | 2023-12-03 21:21:55 | announced | |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: Survival analysis, Mass spectrometry, SWATH-MS, Data analysis,Prostate adenocarcinoma, Gleason grading |
Contact List
Qing Zhong |
contact affiliation | ProCan, Children's Medical Research Institute, University of Sydney |
contact email | qzhong@cmri.org.au |
lab head | |
Zainab Noor |
contact affiliation | ProCan, Children's Medical Research Institute, Faculty of Medicine and Health, The University of Sydney, Westmead, New South Wales, Australia |
contact email | znoor@cmri.org.au |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD041005
- Label: PRIDE project
- Name: Proteomic-based computational stratification of intermediate-risk prostate cancer patients.