PXD040948 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | The heme-responsive PrrH sRNA regulates Pseudomonas aeruginosa pyochelin gene expression |
Description | Pseudomonas aeruginosa is an opportunistic pathogen that requires iron for growth and virulence, yet this nutrient is sequestered by the innate immune system during infection. When iron is limiting, P. aeruginosa expresses the PrrF1 and PrrF2 small regulatory RNAs (sRNAs), which post-transcriptionally repress expression of non-essential iron-containing proteins thus sparing this nutrient for more critical processes.The genes for the PrrF1 and PrrF2 sRNAs are arranged in tandem on the chromosome, allowing for the transcription of a longer heme-responsive sRNA, termed PrrH. While the functions of PrrF1 and PrrF2 have been studied extensively, the role of PrrH in P. aeruginosa physiology and virulence is not well understood. In this study, we performed transcriptomic and proteomic studies to identify the PrrH regulon. |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-22 |
AnnouncementXML | Submission_2024-10-22_06:00:08.222.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Mehari Weldemariam |
SpeciesList | scientific name: Pseudomonas aeruginosa; NCBI TaxID: 287; |
ModificationList | monohydroxylated residue; deamidated residue; iodoacetamide derivatized residue |
Instrument | Orbitrap Fusion Lumos |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2023-03-17 10:22:26 | ID requested | |
1 | 2023-08-11 13:26:38 | announced | |
⏵ 2 | 2024-10-22 06:00:08 | announced | 2024-10-22: Updated project metadata. |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: Pseudomonas aeruginosa, heme-responsive, iron, PrrF1 |
Contact List
Maureen A. Kane |
contact affiliation | Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, MD USA |
contact email | mkane@rx.umaryland.edu |
lab head | |
Mehari Weldemariam |
contact affiliation | University of Maryland Baltimore |
contact email | mweldemariam@rx.umaryland.edu |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD040948
- Label: PRIDE project
- Name: The heme-responsive PrrH sRNA regulates Pseudomonas aeruginosa pyochelin gene expression