PXD040818 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Proteomic mapping reveals dysregulated angiogenesis in the cerebral arteries of rats with early-onset hypertension |
Description | Using data-independent acquisition-based mass spectrometry analysis, we determined the protein changes in cerebral arteries in pre- and early-onset hypertension from the spontaneously hypertensive rat (SHR), a model that resembles essential hypertension. Our analysis identified 125 proteins with expression levels that were significantly up- or downregulated in 12-week old SHRs compared to normotensive Wistar Kyoto rats. Using an angiogenesis enrichment analysis, we identified a critical imbalance in angiogenic proteins, promoting an anti-angiogenic profile in cerebral arteries at the early-onset of hypertension. In a comparison to previously published data, we demonstrate that this angiogenic imbalance is not present in mesenteric and renal arteries from age-matched SHRs. Finally, we identified two proteins (Fbln5 and Cdh13), whose expression levels were critically altered in cerebral arteries compared to the other arterial beds. The observation of an angiogenic imbalance in cerebral arteries from the SHR reveals critical protein changes in the cerebrovasculature at the early-onset of hypertension and provides novel insight into the early pathology of cerebrovascular disease. |
HostingRepository | PRIDE |
AnnounceDate | 2023-11-14 |
AnnouncementXML | Submission_2023-11-14_09:04:37.266.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Joakim Bastrup |
SpeciesList | scientific name: Rattus norvegicus (Rat); NCBI TaxID: 10116; |
ModificationList | No PTMs are included in the dataset |
Instrument | timsTOF |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2023-03-13 09:54:41 | ID requested | |
1 | 2023-09-20 09:50:33 | announced | |
⏵ 2 | 2023-11-14 09:04:37 | announced | 2023-11-14: Updated project metadata. |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: TimsTOF Pro, DIA, cerebral artery, rat,angiogenesis, hypertension |
Contact List
Thomas Jepps |
contact affiliation | Department of Biomedical Sciences, Panum Institute, University of Copenhagen, Blegdamsvej 3, 2200 Copenhagen N, Denmark. |
contact email | tjepps@sund.ku.dk |
lab head | |
Joakim Bastrup |
contact affiliation | Department of Biomedical Sciences, University of Copenhagen, Denmark |
contact email | joakimbastrup@hotmail.dk |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/09/PXD040818 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD040818
- Label: PRIDE project
- Name: Proteomic mapping reveals dysregulated angiogenesis in the cerebral arteries of rats with early-onset hypertension