<<< Full experiment listing

PXD040750

PXD040750 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleProteogenomic Landscape of Breast Ductal Carcinoma Reveals Tumor Progression Characteristics and Therapeutic Targets
DescriptionIn this study, we performed integrated multi-omics analyses using genomic (n = 79), transcriptomic (n = 42), proteomic (n = 224), and phosphoproteomic (n = 49) data collected from 224 samples from 168 patients with malignant and benign breast diseases. Our data revealed the characteristics of the linear multi-step progression of BRDC and provided a resource to explore the temporal order of a series of biological events in the progression of BRDC. In addition, we identified potential therapeutic agents, aspirin and dydrogesterone, that target AKR1C1 and demonstrated their inhibitory effect on tumor cells. In summary, our study helps to understand the progression of BRDC and provides an opportunity to treat BRDC in different stages.
HostingRepositoryiProX
AnnounceDate2024-08-02
AnnouncementXMLSubmission_2024-08-02_04:29:27.107.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterGanfei Xu
SpeciesList scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationListNo PTMs are included in the dataset
InstrumenttimsTOF Pro
Dataset History
RevisionDatetimeStatusChangeLog Entry
02023-03-09 20:06:10ID requested
12024-08-02 04:29:27announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: Breast ductal carcinoma, Progression, Proteogenomics, Sterol hormone receptor conversion, AKR1C1
Contact List
Chen Ding
contact affiliationFudan University
contact emailchend@fudan.edu.cn
lab head
Ganfei Xu
contact affiliationFudan University
contact emailganfeix@fudan.edu.cn
dataset submitter
Full Dataset Link List
iProX dataset URI