PXD040750
PXD040750 is an original dataset announced via ProteomeXchange.
Dataset Summary
Title | Proteogenomic Landscape of Breast Ductal Carcinoma Reveals Tumor Progression Characteristics and Therapeutic Targets |
Description | In this study, we performed integrated multi-omics analyses using genomic (n = 79), transcriptomic (n = 42), proteomic (n = 224), and phosphoproteomic (n = 49) data collected from 224 samples from 168 patients with malignant and benign breast diseases. Our data revealed the characteristics of the linear multi-step progression of BRDC and provided a resource to explore the temporal order of a series of biological events in the progression of BRDC. In addition, we identified potential therapeutic agents, aspirin and dydrogesterone, that target AKR1C1 and demonstrated their inhibitory effect on tumor cells. In summary, our study helps to understand the progression of BRDC and provides an opportunity to treat BRDC in different stages. |
HostingRepository | iProX |
AnnounceDate | 2024-08-02 |
AnnouncementXML | Submission_2024-08-02_04:29:27.107.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Ganfei Xu |
SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
ModificationList | No PTMs are included in the dataset |
Instrument | timsTOF Pro |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
---|---|---|---|
0 | 2023-03-09 20:06:10 | ID requested | |
⏵ 1 | 2024-08-02 04:29:27 | announced |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: Breast ductal carcinoma, Progression, Proteogenomics, Sterol hormone receptor conversion, AKR1C1 |
Contact List
Chen Ding | |
---|---|
contact affiliation | Fudan University |
contact email | chend@fudan.edu.cn |
lab head | |
Ganfei Xu | |
contact affiliation | Fudan University |
contact email | ganfeix@fudan.edu.cn |
dataset submitter |
Full Dataset Link List
iProX dataset URI |