PXD040666

PXD040666 is an original dataset announced via ProteomeXchange.

Title	The effect of cannabinoid receptor agonists on triple-negative breast cancer cell line (MDA-MB-231)
Description	The endocannabinoid system (ECS) provides regulatory functions in several cellular and physiological processes. It has also been found to play a role in control of cancer development. Our group found that breast cancer cells responded to cannabinoid receptor (CB) agonist treatments. This leads the activation of CB receptors in breast cancer, which inhibited their growth. In addition, breast cancer cells also behaved differentially when they were exposed to combinations of both CB1 and CB2 agonists. The underlying mechanism of individual- or co- activation after CB agonist exposure is still unknown. Hence, we studied the impact of CB activation on cancer molecular signature by performing proteomic analysis after triple-negative breast cancer (MDA-MB-231) cells exposed to CB receptor agonists. In this study, ACEA and GW405833 were used as CB1 and CB2 receptor agonists, respectively.
HostingRepository	PRIDE
AnnounceDate	2024-07-27
AnnouncementXML	Submission_2024-07-27_01:48:46.995.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Chartinun Chutoe
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2023-03-07 17:05:28	ID requested
⏵ 1	2024-07-27 01:48:47	announced

Dataset with its publication pending

submitter keyword: breast cancer, triple-negative, proteomics, cannabinoid receptor agonists,human, endocannabinoid

Kornkamon Lertsuwan
contact affiliation	Department of Biochemistry, Faculty of Science, Mahidol University, Bangkok, Thailand
contact email	kornkamon.ler@mahidol.edu
lab head
Chartinun Chutoe
contact affiliation	Department of Biochemistry, Faculty of Science, Mahidol University, Bangkok, Thailand
contact email	chartinun.c@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/07/PXD040666

PRIDE project URI

• PRIDE
  1. PXD040666
     1. Label: PRIDE project
     2. Name: The effect of cannabinoid receptor agonists on triple-negative breast cancer cell line (MDA-MB-231)