PXD040624
PXD040624 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Integrative systems biology characterizes immune-mediated neurodevelopmental changes in murine Zika Virus microcephaly |
| Description | A new mouse model for congenital Zika infection in a wildtype, immunocompetent background employing intraplacental infection resulted in productive infection of embryonic brains and features of microcephaly during early development (E10.5-16.5). Gross morphological characterization showed translational relevance for understanding the viral neuropathogenesis and Zika-associated microcephaly in humans. Thus, an integrated, multi-omics (RNA-sequencing, proteomics) analysis of fetal brain tissues was performed to understand pathways perturbed by viral infection in developing brains. These analyses identified virus-induced defects in cell cycle progression and neurodevelopment, in S-phase DNA replication and NEUROD2/TBR2 transcription factor cascades, respectively. Among the most significant responses was induction of innate immune programs in ZIKV-infected brains, including immunoproteasome activation and MHC-I antigen display associated with immune cell infiltration and neuronal death during early development. Identification of specific components within major pathways contributing to viral infection-induced effects on neurodevelopment provides novel targets for therapeutic intervention against neurotropic infections and ZIKV-associated microcephaly specifically. |
| HostingRepository | MassIVE |
| AnnounceDate | 2023-06-01 |
| AnnouncementXML | Submission_2023-06-01_07:40:27.815.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Non peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Amanda Guise |
| SpeciesList | scientific name: Mus musculus; common name: house mouse; NCBI TaxID: 10090; |
| ModificationList | TMT; S-carboxamidoethyl-L-cysteine; L-methionine sulfone |
| Instrument | Q Exactive HF |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2023-03-06 08:28:03 | ID requested | |
| ⏵ 1 | 2023-06-01 07:40:28 | announced |
Publication List
| no publication |
Keyword List
| submitter keyword: Zika virus, immunoproteasome, cortex, neurodevelopment, innate immunity, neurotropic infection, microcephaly |
Contact List
| Judith A. Steen | |
|---|---|
| contact affiliation | Boston Children's Hospital & Harvard Medical School |
| contact email | judith.steen@childrens.harvard.edu |
| lab head | |
| Amanda Guise | |
| contact affiliation | Boston Children's Hospital |
| contact email | amanda.guise@gmail.com |
| dataset submitter | |
Full Dataset Link List
| MassIVE dataset URI |
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive.ucsd.edu/MSV000091415/ |
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