PXD040434

PXD040434 is an original dataset announced via ProteomeXchange.

Title	Human adipose tissue proteomics reveal adaptations to exercise and type 2 diabetes
Description	White adipose tissue (WAT) plays a critical role in whole-body energy homeostasis. In this study, we established the differential proteomic signatures of WAT in glucose-tolerant lean and obese individuals and patients with type 2 diabetes (T2D) and in response to 8 weeks of high intensity interval training (HIIT). We combined a high-throughput and reproducible mass spectrometry-based proteomics pipeline and identified a total of 3773 proteins. We find that a majority of regulated proteins displayed progression from lean to obese and T2D individuals and were highly associated with clinical measures of glucose homeostasis (e.g., insulin sensitivity, HbA1c) and they could, therefore, serve as potential disease biomarkers. Interestingly, HIIT induced a strong increase in WAT ferritin levels independent of group. WAT ferritin levels strongly correlated with individual insulin sensitivity. Thus, we report novel proteomic signatures of WAT related to obesity and T2D and highlight an unrecognized role of human WAT iron metabolism in exercise training adaptations.
HostingRepository	PRIDE
AnnounceDate	2024-01-10
AnnouncementXML	Submission_2024-01-10_04:27:19.306.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Diana Samodova-Sommer
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Exploris 480

Revision	Datetime	Status	ChangeLog Entry
0	2023-02-27 06:00:13	ID requested
⏵ 1	2024-01-10 04:27:19	announced

Dataset with its publication pending

submitter keyword: White adipose tissue, High intensity interval training, Proteomics, Insulin resistance, iron metabolism

Atul Shahaji Deshmukh
contact affiliation	Assoc. Prof. at Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark
contact email	atul.deshmukh@sund.ku.dk
lab head
Diana Samodova-Sommer
contact affiliation	Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen
contact email	diana.samodova@sund.ku.dk
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/01/PXD040434

PRIDE project URI

• PRIDE
  1. PXD040434
     1. Label: PRIDE project
     2. Name: Human adipose tissue proteomics reveal adaptations to exercise and type 2 diabetes